S
Sophie Tan-Chen
Researcher at University of Paris
Publications - 5
Citations - 118
Sophie Tan-Chen is an academic researcher from University of Paris. The author has contributed to research in topics: Ceramide & Insulin. The author has an hindex of 3, co-authored 4 publications receiving 65 citations. Previous affiliations of Sophie Tan-Chen include Institute of Chartered Accountants of Nigeria.
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Journal ArticleDOI
Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells
Cécile L. Bandet,Sophie Tan-Chen,Sophie Tan-Chen,Olivier Bourron,Olivier Bourron,Hervé Le Stunff,Eric Hajduch,Eric Hajduch +7 more
TL;DR: The latest progress involving ceramides as major players in the development of muscle insulin-resistance through the targeting of selective actors of the insulin signaling pathway is described.
Journal ArticleDOI
Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes.
Jeanne Guitton,Cécile L. Bandet,Mohamed Lamine Mariko,Sophie Tan-Chen,Olivier Bourron,Olivier Bourron,Yacir Benomar,Eric Hajduch,Eric Hajduch,Hervé Le Stunff +9 more
TL;DR: It is demonstrated that S1P can display opposite effects on insulin sensitive tissues and pancreatic β cells, which depends on its origin or its degradation pathway.
Journal ArticleDOI
Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology.
Sophie Tan-Chen,Sophie Tan-Chen,Jeanne Guitton,Olivier Bourron,Olivier Bourron,Hervé Le Stunff,Eric Hajduch,Eric Hajduch +7 more
TL;DR: It is shown that modulating sphingolipid metabolism may be a novel and interesting way for preventing and/or treating several muscle-related diseases.
Journal ArticleDOI
[Ceramides, crucial actors in the development of insulin resistance and type 2 diabetes].
TL;DR: Cette revue decrit le role majeur joue par les ceramides dans le developpement de l’insulino-resistance des tissus peripheriques, joues un role crucial dansl’alteration du message insulinique.
Journal ArticleDOI
Ceramide analog C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway
Cécile L. Bandet,Sophie Tan-Chen,Mélanie Campana,Maxime Poirier,Agnieszka Blachnio-Zabielska,J. P. Pais-De-Barros,Claude Rouch,Pascal Ferré,Fabienne Foufelle,Hervé Le Stunff,Eric Hajduch +10 more
TL;DR: In this paper , the authors showed that C2-cer enters the salvage/recycling pathway and becomes deacylated, yielding sphingosine, which depends on the availability of long chain fatty acids provided by the lipogenesis pathway in muscle cells.