Hervé Le Stunff

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; A Frozena, AA; Adachi, H, Adeli, K, Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello, M; Agostinis, P; Aguilar, PV; Aguirre-Ghis

TL;DR: Interestingly, attenuating the increase in levels of hypothalamic ceramides with intracerebroventricular infusion of myriocin in OZR improved their hypothalamic insulin-sensitivity, and this latter effect is related to the restoration of glucose-stimulated insulin secretion and an increase in β-cell mass of OzR.

TL;DR: Results suggest that activation of palmitate-induced SphK1-mediated sphingoid base-1-phosphate formation in the ER of β cells plays a protective role against palmitates-induced ceramide-dependent apoptotic β cell death.

TL;DR: The role of homocysteine and ceramide metabolism linking metabolic diseases and non-alcoholic fatty liver disease to AD is examined and the expression of mainly enzymes implicated in ceramide and sphingolipid metabolism is analyzed and deregulation of de novo ceramide biosynthesis and S1P metabolism in liver and brain of hyperhomocysteinemic mice is demonstrated.