Sören Boller

TL;DR: This study provides new insights into the genetic basis of follicular lymphoma and the clonal dynamics of transformation and suggests that personalizing therapies to target key genetic alterations in the CPC represents an attractive therapeutic strategy.

TL;DR: It is found that Ebf1 is required for the proliferation, survival, and signaling of pro-B cells and peripheral B-cell subsets, including B1 cells and marginal zone B cells, and regulates both common and distinct sets of genes in early and late stage B cells.

TL;DR: A model in which extrinsic signals and intrinsic cues establish a permissive chromatin context upon which a regulatory network of transcription factors and epigenetic modifiers act to guide the differentiation of hematopoietic lineages is proposed.

TL;DR: It is shown that the EBF1 C-terminal domain (CTD) is required for the regulation of a specific gene set involved in B cell fate decision and differentiation, independently of activation and repression functions.

TL;DR: It is shown in a time-resolved analysis that E BF1 occupancy coincides with EBF1 expression and precedes the formation of chromatin accessibility, which allows for an ordered sequence of epigenetic and transcriptional events in B-cell programming.