N
Nikolay Popov
Researcher at Queen Mary University of London
Publications - 11
Citations - 2705
Nikolay Popov is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Senescence & Gene. The author has an hindex of 6, co-authored 10 publications receiving 2303 citations. Previous affiliations of Nikolay Popov include Imperial College London & Hammersmith Hospital.
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Journal ArticleDOI
Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
Juan C. Acosta,Ana O'Loghlen,Ana Banito,Maria V. Guijarro,Arnaud Augert,Selina Raguz,Marzia Fumagalli,Marco Da Costa,Celia Brown,Nikolay Popov,Yoshihiro Takatsu,Jonathan Melamed,Fabrizio d'Adda di Fagagna,David Bernard,Eva Hernando,Jesús Gil +15 more
TL;DR: It is reported that knocking down the chemokine receptor CXCR2 (IL8RB) alleviates both replicative and oncogene-induced senescence (OIS) and diminishes the DNA-damage response and suggests that senescent cells activate a self-amplifying secretory network in which CX CR2-binding chemokines reinforce growth arrest.
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Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
Jessica Okosun,Csaba Bödör,Jun Wang,Shamzah Araf,Cheng Yuan Yang,Chenyi Pan,Sören Boller,Davide Cittaro,Monika Bozek,Sameena Iqbal,Janet Matthews,David Wrench,Jacek Marzec,Kiran Tawana,Nikolay Popov,Ciaran O'Riain,Derville O’Shea,Emanuela Carlotti,Andrew Davies,Charles H. Lawrie,András Matolcsy,Maria Calaminici,Andrew Norton,Richard J. Byers,Charles A. Mein,Elia Stupka,T. Andrew Lister,Georg Lenz,Silvia Montoto,John G. Gribben,Yuhong Fan,Rudolf Grosschedl,Claude Chelala,Jude Fitzgibbon +33 more
TL;DR: This study provides new insights into the genetic basis of follicular lymphoma and the clonal dynamics of transformation and suggests that personalizing therapies to target key genetic alterations in the CPC represents an attractive therapeutic strategy.
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EZH2 mutations are frequent and represent an early event in follicular lymphoma
Csaba Bödör,Csaba Bödör,Vera Grossmann,Nikolay Popov,Jessica Okosun,Ciaran O'Riain,King Tan,Jacek Marzec,Shamzah Araf,Jun Wang,Abigail M. Lee,Andrew Clear,Silvia Montoto,Janet Matthews,Sameena Iqbal,Hajnalka Rajnai,Andreas Rosenwald,German Ott,German Ott,Elias Campo,Lisa M. Rimsza,Erlend B. Smeland,Erlend B. Smeland,Wing C. Chan,Rita M. Braziel,Louis M. Staudt,George E. Wright,T. Andrew Lister,Olivier Elemento,Robert Kerrin Hills,John G. Gribben,Claude Chelala,András Matolcsy,Alexander Kohlmann,Torsten Haferlach,Randy D. Gascoyne,Jude Fitzgibbon +36 more
TL;DR: Overall, the high incidence of EZH2 mutations in FL and their stability during disease progression makes FL an appropriate disease to evaluate EZh2 targeted therapy.
Journal ArticleDOI
Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health.
Nikolay Popov,Jesús Gil +1 more
TL;DR: To understand the intimate involvement of the INK4b-ARF-INK4a locus on disease, to understand its regulation is the first step for manipulate it to therapeutic benefit.
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Functional Crosstalk between Bmi1 and MLL/Hoxa9 Axis in Establishment of Normal Hematopoietic and Leukemic Stem Cells
Lan-Lan Smith,Jenny Yeung,Bernd B. Zeisig,Nikolay Popov,Ivo J. Huijbers,Josephine Barnes,Amanda Wilson,Erdogan Taskesen,Ruud Delwel,Jesús Gil,Maarten van Lohuizen,Chi Wai Eric So,Chi Wai Eric So +12 more
TL;DR: Results reveal an important functional interplay between MLL/Hox and Bmi1 in regulating cellular senescence for LSC development, suggesting that a synergistic targeting of both molecules is required to eradicate a broader spectrum of LSCs.