Søren Jepsen

TL;DR: A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined and the deduced amino acid sequence contains 2 repeat regions.

TL;DR: This strain of chloroquine-resistant Plasmodium falciparum malaria in a non-immune male shows a resistance pattern of R I delayed recrudescence, and should be treated with Fansidar if continuous treatment of the patient with lithium does not interfere with the schizontocidal action ofchloroquine.

TL;DR: It is demonstrated thatGLURP produced in E. coli can induce a humoral immune response against GLURP derived from blood-stage parasites.

TL;DR: The results of the first phase Ia clinical trial of GMZ2 adjuvanted in aluminium hydroxide conclude thatGMZ2 is a safe and immunogenic malaria vaccine candidate suitable for further clinical development.

TL;DR: Data show that levels of the GLURP-specific IgG that occurs in the nonrepeat region of the antigen are significantly correlated with clinical protection from P. falciparum malaria, lending support to the hypothesis that antibody-dependent cellular inhibition is the important element in GLURp-specific protective immunity.