Kwadwo A. Koram

TL;DR: These findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations.

TL;DR: This study shows that adults from an area of hyperendemic P. falciparum transmission generally possessed low levels of Abs specifically recognizing surface Ags expressed by a CSA-adhering parasite isolate, while unselected isolates were well recognized, and supports the hypothesis that Abs inhibiting C SA-specific parasite sequestration are important in acquisition of protection against PAM.

TL;DR: The relationship between malaria-related outcomes and cytokine production in whole blood cultures associated with cellular immune responses and immunity to Plasmodium falciparum malaria was examined and high ratios of proinflammatory to anti-inflammatory cytokines were associated with increased risk of fever and higher hemoglobin concentrations.

TL;DR: Though the human dwellings in the study communities conferred no real protection against mosquitoes, bednet usage was low while residents combatted the nuisance of mosquitoes with insecticide sprays, burning of coils and herbs, which they largely considered as temporary measures.

TL;DR: Analysis of sequence variation in diverse human populations shows that the KIR3DL1/S1 locus encodes two lineages of polymorphic inhibitory KIR2DL1 allotypes that recognize Bw4 epitopes of protein">HLA-A and HLA-B and one lineage of conserved activating Kir3DS1 allotype, also implicated in Bw 4 recognition.