Sorina Radulescu

TL;DR: Using this resource, it is found—and confirm by independent approaches—that the proposed quiescent/‘+4’ stem cell markers Bmi1, Tert, Hopx and Lrig1 are robustly expressed in CBC cells.

TL;DR: It is found that during biliary regeneration, expression of Jagged 1 by myofibroblasts promoted Notch signaling in HPCs and thus their biliary specification to cholangiocytes and thus the promotion of their specification to hepatocytes.

TL;DR: This model predicts that the mTOR inhibitor rapamycin, which does not efficiently inhibit 4EBP1, would be ineffective in limiting cancer progression in APC-deficient lesions, and suggests that inhibition of translation elongation using existing, clinically approved drugs, such as the rapalogs, would provide clear therapeutic benefit for patients at high risk of developing colorectal cancer.

TL;DR: In this study, it is shown that after Apc deletion, the cellular iron acquisition proteins TfR1 and DMT1 are rapidly induced, and restoration of APC reduces cellular iron due to repression of these proteins.

TL;DR: Data show that deregulated Wnt signalling has a critical role in promoting UCC, and suggests that human UCC that have high levels of Wnt and PI3 kinase signalling may be responsive to mTOR inhibition.