S
Sotirios Totokotsopoulos
Researcher at Rice University
Publications - 10
Citations - 339
Sotirios Totokotsopoulos is an academic researcher from Rice University. The author has contributed to research in topics: Diketopiperazines & Erythrose. The author has an hindex of 7, co-authored 10 publications receiving 297 citations. Previous affiliations of Sotirios Totokotsopoulos include University of California, San Diego & Scripps Research Institute.
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Journal ArticleDOI
Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents.
Kyriacos C. Nicolaou,Min Lu,Sotirios Totokotsopoulos,Philipp Heretsch,Denis Giguère,Ya Ping Sun,David Sarlah,Thu Han Nguyen,Ian Coulter Wolf,Donald F. Smee,Craig W. Day,Selina Bopp,Elizabeth A. Winzeler +12 more
TL;DR: Biological screening of selected synthesized compounds led to the discovery of a number of nanomolar antipoliovirus agents and several low-micromolar anti- Plasmodium falciparum lead compounds.
Journal ArticleDOI
Total Synthesis of Epicoccin G
TL;DR: An expedient enantioselective total synthesis of epicoccin G and related dithiodiketopiperazines through a strategy featuring direct two-directional sulfenylation, photooxygenation, and Kornblum-DeLaMare rearrangement is described.
Journal ArticleDOI
Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs
Kyriacos C. Nicolaou,Dionisios Vourloumis,Sotirios Totokotsopoulos,Athanasios Papakyriakou,Holger Karsunky,Hanan Fernando,Julia Gavrilyuk,Damien Webb,Antonia F. Stepan +8 more
TL;DR: A convenient synthesis ofImatinib, a potent inhibitor of ABL1 kinase and widely prescribed drug for the treatment of a variety of leukemias, was devised and applied to the construction of a series of novel imatinib analogues featuring a number of non‐aromatic structural motifs in place of the parent molecule's phenyl moiety.
Journal ArticleDOI
A Practical Sulfenylation of 2,5‐Diketopiperazines
Kyriacos C. Nicolaou,Denis Giguère,Denis Giguère,Sotirios Totokotsopoulos,Sotirios Totokotsopoulos,Ya Ping Sun,Ya Ping Sun +6 more
TL;DR: Sulfurs in action A practical and simple method for the introduction of sulfur atoms into 2,5-diketopiperazines under mild conditions has been developed leading to more or less complex epidithiodiketipiperazines (II) and bis-methylthiodikETopiperazine (III).
Journal ArticleDOI
Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues
Kyriacos C. Nicolaou,Derek Rhoades,Derek Rhoades,Yanping Wang,Sotirios Totokotsopoulos,Sotirios Totokotsopoulos,Ruoli Bai,Ernest Hamel +7 more
TL;DR: Cytotoxicity studies and tubulin binding assays revealed two of these analogues to be more potent than epothilones A–D and the anticancer agent ixabepilone, currently in clinical use.