S
Selina Bopp
Researcher at Harvard University
Publications - 32
Citations - 2235
Selina Bopp is an academic researcher from Harvard University. The author has contributed to research in topics: Plasmodium falciparum & Drug resistance. The author has an hindex of 19, co-authored 30 publications receiving 1836 citations. Previous affiliations of Selina Bopp include Broad Institute & University of California, San Diego.
Papers
More filters
Journal ArticleDOI
Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery
Stephan Meister,David Plouffe,Kelli Kuhen,Ghislain M. C. Bonamy,Tao Wu,S. Whitney Barnes,Selina Bopp,Rachel Borboa,A. Taylor Bright,A. Taylor Bright,Jianwei Che,Steve Cohen,Neekesh V. Dharia,Kerstin Gagaring,Montip Gettayacamin,Perry Gordon,Todd Groessl,Nobutaka Kato,Marcus C. S. Lee,Case W. McNamara,David A. Fidock,Advait Nagle,Tae-gyu Nam,Wendy Richmond,Jason Roland,Matthias Rottmann,Matthias Rottmann,Bin Zhou,Patrick Froissard,Patrick Froissard,Richard Glynne,Dominique Mazier,Dominique Mazier,Jetsumon Sattabongkot,Peter G. Schultz,Tove Tuntland,John R. Walker,Yingyao Zhou,Arnab K. Chatterjee,Thierry T. Diagana,Elizabeth A. Winzeler,Elizabeth A. Winzeler +41 more
TL;DR: An imidazolopiperazine scaffold series was identified that was highly enriched among compounds active against Plasmodium liver stages and shows potent in vivo blood-stage therapeutic activity.
Journal ArticleDOI
Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum
Nicolas M. B. Brancucci,Joseph P. Gerdt,Chengqi Wang,Mariana De Niz,Nisha Philip,Swamy R. Adapa,Min Zhang,Eva Hitz,Igor Niederwieser,Sylwia D. Boltryk,Marie-Claude Laffitte,Martha A. Clark,Christof Grüring,Deepali Ravel,Alexandra Blancke Soares,Allison Demas,Selina Bopp,Belén Rubio-Ruiz,Ana Conejo-García,Dyann F. Wirth,Edyta Gendaszewska-Darmach,Manoj T. Duraisingh,John H. Adams,Till S. Voss,Andrew P. Waters,Rays H. Y. Jiang,Jon Clardy,Matthias Marti,Matthias Marti +28 more
TL;DR: It is shown that the host-derived lipid lysophosphatidylcholine (LysoPC) controls P. falciparum cell fate by repressing parasite sexual differentiation, and a major component of the sexual differentiation pathway in Plasmodium is introduced that may provide new approaches for blocking malaria transmission.
Journal ArticleDOI
Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families.
Selina Bopp,Micah J. Manary,A. Taylor Bright,Geoffrey Johnston,Neekesh V. Dharia,Fabio Luna,Susan McCormack,David Plouffe,Case W. McNamara,John R. Walker,David A. Fidock,Eros Lazzerini Denchi,Elizabeth A. Winzeler,Elizabeth A. Winzeler +13 more
TL;DR: This work studied the complete genomes of different Plasmodium falciparum clones that had been propagated asexually over one year in the presence and absence of drug pressure to model the frequency at which drug or immune resistance alleles will emerge under a well-defined set of assumptions.
Journal ArticleDOI
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Annie N. Cowell,Eva S. Istvan,Amanda K. Lukens,Amanda K. Lukens,Maria G. Gomez-Lorenzo,Manu Vanaerschot,Tomoyo Sakata-Kato,Erika L. Flannery,Pamela Magistrado,Edward Owen,Matthew Abraham,Gregory LaMonte,Heather J. Painter,Roy Williams,Virginia Franco,María Linares,Ignacio Arriaga,Selina Bopp,Victoria C. Corey,Nina F. Gnädig,Olivia Coburn-Flynn,Christin Reimer,Purva Gupta,James M. Murithi,Pedro A. Moura,Olivia Fuchs,Erika Sasaki,Sang W. Kim,Christine H. Teng,Lawrence T. Wang,Aslı Akidil,Sophie H. Adjalley,Paul Willis,Dionicio Siegel,Olga Tanaseichuk,Yang Zhong,Yingyao Zhou,Manuel Llinás,Sabine Ottilie,Francisco-Javier Gamo,Marcus C. S. Lee,Marcus C. S. Lee,Daniel E. Goldberg,David A. Fidock,Dyann F. Wirth,Dyann F. Wirth,Elizabeth A. Winzeler,Elizabeth A. Winzeler +47 more
TL;DR: Genome sequencing elucidates potential drug resistance in the malaria parasite and identifies antimalarial targets and drug-resistance genes, as well as discovering hitherto unrecognized drug target–inhibitor pairs.
Journal ArticleDOI
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum
Neekesh V. Dharia,Amar Bir Singh Sidhu,Amar Bir Singh Sidhu,Maria B. Cassera,Scott J. Westenberger,Selina Bopp,Richard T. Eastman,David Plouffe,Serge Batalov,Daniel J. Park,Sarah K. Volkman,Sarah K. Volkman,Dyann F. Wirth,Dyann F. Wirth,Yingyao Zhou,David A. Fidock,Elizabeth A. Winzeler,Elizabeth A. Winzeler +17 more
TL;DR: Tiling microarrays can detect de novo a large proportion of the genetic changes that differentiate one genome from another and newly emerged single nucleotide polymorphisms can readily be detected, showing that malaria parasites can rapidly acquire gene amplifications in response to in vitro drug pressure.