Soumaya Zlitni

TL;DR: The study suggests that small proteins are highly abundant and those of the human microbiome, in particular, may perform diverse functions that have not been previously reported.

TL;DR: Chertow et al. as discussed by the authors analyzed the dynamics of fecal RNA shedding up to 10 months after COVID-19 diagnosis in 113 individuals with mild to moderate disease, followed for 10 months post-diagnosis.

TL;DR: It is demonstrated that the targets of well-known antibiotics can be identified as high copy suppressors of chemical lethality and MAC13243, a molecule that belongs to a new chemical class and that has a unique mechanism and promising activity against multidrug-resistant Pseudomonas aeruginosa, is discovered.

TL;DR: The gene encodes a nucleolar protein of unknown function, and the cellular phenotype observed in patient lymphoblasts implicates a role for the nucleolus in the pathogenesis of this disease.

TL;DR: It is concluded that metabolite suppression profiling is an effective approach to focus MOA studies on compounds impairing metabolic capabilities and can serve as chemical probes of bacterial physiology and as leads for antibacterial drug development.