Sowmyalakshmi Rasika

TL;DR: Triggering ERK signaling in tanycytes with EGF reestablishes leptin transport, elicits MBH neuron activation and energy expenditure in obese animals, and accelerates the restoration of leptin sensitivity upon the return to a normal-fat diet.

TL;DR: It is reported that a multilayered microRNA-operated switch with built-in feedback governs increased GnRH expression during the infantile-to-juvenile transition and that impairing microRNA synthesis in GnRH neurons leads to hypogonadotropic hypog onadotropicism and infertility in mice.

TL;DR: Tissue-clearing and imaging of intact human embryos reveals previously unprecedented GnRH neuron target sites and routes of migration into the brain, revealing not only that the number of GnRH-immunoreactive neurons in humans is significantly higher than previously thought, but that GnRH cells migrate into several extrahypothalamic brain regions in addition to the hypothalamus.

TL;DR: Pools of morphologically, antigenically, and topographically diverse neural progenitor cells are present in the human hippocampus from early developmental stages until adulthood, including in AD patients, while their neurogenic potential seems negligible in the adult.

TL;DR: The key roles of the Golgi apparatus in post‐mitotic neurons and the oligodendrocytes that myelinate them are reviewed, and an overview of these Golgi‐associated POM‐causing genes, their function in Golgi organization and trafficking and the likely mechanisms that may link dysfunctions in RAB‐dependent regulatory pathways with POM are provided.