Spasenija Savic

TL;DR: T-DM1 is particularly effective in eliciting antitumor immunity in patients with early breast cancer and in a HER2-expressing orthotopic tumor model, and it is shown that it can be used in combination therapy.

TL;DR: Multivariable models, adjusted for patient, tumor, and treatment characteristics, and matched cohort analysis confirmed that ALK FISH positivity is a predictor for better overall survival (OS) and a screening strategy based on IHC or H-score could be envisaged.

TL;DR: It is demonstrated that the dolastatin family of microtubule inhibitors, from which the cytotoxic component of brentuximab vedotin is derived, comprises potent inducers of phenotypic and functional dendritic cell (DC) maturation and homing to draining lymph nodes to potentiate cellular antitumor immune responses in patients.

TL;DR: In this paper, the authors compared the HER2 status on cytological specimens of distant metastases with the result from the primary carcinomas, and explored the prevalence of and the reasons for discrepant results.

TL;DR: The high FISH-positive rate of NSCLC on cytological specimens contrasts with the low rate on biopsies when previously suggested criteria are used, suggesting new criteria for a positive EGFR FISH status to predict response to therapy with EGFR-TKI need to be defined for cytological specimen.