V
Victor V. Lobanenkov
Researcher at National Institutes of Health
Publications - 108
Citations - 18865
Victor V. Lobanenkov is an academic researcher from National Institutes of Health. The author has contributed to research in topics: CTCF & Chromatin. The author has an hindex of 58, co-authored 105 publications receiving 17484 citations. Previous affiliations of Victor V. Lobanenkov include Sangamo BioSciences & University of Giessen.
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Journal ArticleDOI
Histone modifications at human enhancers reflect global cell-type-specific gene expression
Nathaniel D. Heintzman,Gary C. Hon,R. David Hawkins,Pouya Kheradpour,Alexander Stark,Alexander Stark,Lindsey F. Harp,Zhen Ye,Leonard K. Lee,Rhona K. Stuart,Christina W. Ching,Keith A. Ching,Jessica Antosiewicz-Bourget,Hui Liu,Xinmin Zhang,Roland D. Green,Victor V. Lobanenkov,Ron Stewart,James A. Thomson,James A. Thomson,Gregory E. Crawford,Manolis Kellis,Manolis Kellis,Bing Ren +23 more
TL;DR: The results define over 55,000 potential transcriptional enhancers in the human genome, significantly expanding the current catalogue of human enhancers and highlighting the role of these elements in cell-type-specific gene expression.
Journal Article
Histone Modifications at Human Enhancers Reflect Global Cell-Type-Specific Gene Expression
Nathaniel D. Heintzman,Gary C. Hon,R. David Hawkins,Pouya Kheradpour,Alexander Stark,Lindsey F. Harp,Zhen Ye,Leonard K. Lee,Rhona K. Stuart,Christina W. Ching,Keith A. Ching,Jessica Antosiewicz-Bourget,Hui Liu,Xinmin Zhang,Roland D. Green,Victor V. Lobanenkov,Ron Stewart,James A. Thomson,Gregory E. Crawford,Manolis Kellis,Bing Ren +20 more
TL;DR: In this article, a chromatin-immunoprecipitation-based microarray method (ChIP-chip) was used to locate promoters, enhancers and insulators in the human genome and investigate their roles in cell-type specific gene expression.
Journal ArticleDOI
Chromatin architecture reorganization during stem cell differentiation
Jesse R. Dixon,Inkyung Jung,Siddarth Selvaraj,Yin Shen,Jessica Antosiewicz-Bourget,Ah Young Lee,Zhen Ye,Audrey Kim,Nisha Rajagopal,Wei Xie,Yarui Diao,Jing Liang,Huimin Zhao,Victor V. Lobanenkov,Joseph R. Ecker,James A. Thomson,Bing Ren +16 more
TL;DR: Mapping genome-wide chromatin interactions in human embryonic stem cells and four human ES-cell-derived lineages reveals extensive chromatin reorganization during lineage specification, providing a global view of chromatin dynamics and a resource for studying long-range control of gene expression in distinct human cell lineages.
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A map of the cis-regulatory sequences in the mouse genome
Yin Shen,Feng Yue,David F. McCleary,Zhen Ye,Lee Edsall,Samantha Kuan,Ulrich Wagner,Jesse R. Dixon,Jesse R. Dixon,Leonard Lee,Victor V. Lobanenkov,Bing Ren,Bing Ren +12 more
TL;DR: It is shown that much of the mouse genome is organized into domains of coordinately regulated enhancers and promoters, which provides a resource for the annotation of functional elements in the mammalian genome and for the study of mechanisms regulating tissue-specific gene expression.
Journal ArticleDOI
Analysis of the Vertebrate Insulator Protein CTCF-Binding Sites in the Human Genome
Tae Hoon Kim,Ziedulla Abdullaev,Andrew D. Smith,Keith A. Ching,Dmitri Loukinov,Roland Green,Michael Q. Zhang,Victor V. Lobanenkov,Bing Ren +8 more
TL;DR: 13,804 CTCF-binding sites in potential insulators of the human genome are described, discovered experimentally in primary human fibroblasts and fit to a consensus motif highly conserved and suitable for predicting possible insulators driven by CTCf in other vertebrate genomes.