S
Srikanta Goswami
Researcher at Indian Institute of Chemical Biology
Publications - 21
Citations - 750
Srikanta Goswami is an academic researcher from Indian Institute of Chemical Biology. The author has contributed to research in topics: RNA & Transfer RNA. The author has an hindex of 10, co-authored 20 publications receiving 670 citations. Previous affiliations of Srikanta Goswami include University of Wisconsin-Madison.
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Journal ArticleDOI
CRD-BP Protects the Coding Region of βTrCP1 mRNA from miR-183-Mediated Degradation
TL;DR: CRD-BP prevents degradation of betaTrCP1 mRNA by attenuating its miR-183-dependent interaction with Ago2, and is identified as a microRNA that interacts with the coding region of beta Tr CP1 mRNA.
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Role of superoxide dismutase in survival of Leishmania within the macrophage.
TL;DR: Results indicate that SOD is a major determinant of intracellular survival of Leishmania, and cloned a SOD gene from L. tropica and generated SOD-deficient parasites by expressing the corresponding antisense RNA from an episomal vector.
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Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA
Felicite K. Noubissi,Srikanta Goswami,Nicholas A. Sanek,Kazuyuki Kawakami,Toshinari Minamoto,Amy R. Moser,Yevgenya Grinblat,Vladimir S. Spiegelman +7 more
TL;DR: A novel mechanism by which Wnt signaling pathway stimulates the transcriptional output of Hedgehog signaling, causing an elevation of GLI1 expression and transcriptional activity is identified and seems to be important to several functions of Wnt, including survival and proliferation of colorectal cancer cells.
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MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein.
Srikanta Goswami,Rohinton Tarapore,Jessica J. TeSlaa,Yevgenya Grinblat,Vijayasaradhi Setaluri,Vladimir S. Spiegelman +5 more
TL;DR: It is shown that melanoma cells favor the expression of MITF mRNA with shorter 3′-UTR, which is regulated by microRNA, miR-340, and this interplay between RNA-binding protein and miRNA describes the important mechanism of regulation ofMITF in melanocytes and malignant melanomas.
Journal ArticleDOI
MicroRNA-340-mediated Degradation of Microphthalmia-associated Transcription Factor (MITF) mRNA Is Inhibited by Coding Region Determinant-binding Protein (CRD-BP)
Srikanta Goswami,Rohinton Tarapore,Ashley M. Poenitzsch Strong,Jessica J. TeSlaa,Yevgenya Grinblat,Vijayasaradhi Setaluri,Vladimir S. Spiegelman +6 more
TL;DR: It is shown that melanoma cells favor the expression of MITF mRNA with a shorter 3′-UTR, and it is established that this isoform is regulated by a micro RNA (miRNA/miR), miR-340, which contributes to the effects of CRD-BP on melanoma survival and progression.