Srinivas Chamakuri

TL;DR: Protein−Protein Interactions Centered on the Inhibitors of Apoptosis Proteins (IAPs) and Synthetic Small Molecules and their Derivatives, and the Unexpected Discovery of First Bivalent SMAC Mimetic AF.

TL;DR: It is discovered that mis-spliced RNA itself is a molecular trigger for tumor killing through viral mimicry, indicating that dsRNA-sensing pathways respond to global aberrations of RNA splicing in cancer and provoking the hypothesis that STTs may provide unexplored strategies to activate anti-tumor immune pathways.

TL;DR: In this paper, an affinity-based screen of 4 billion DNA-encoded molecules en masse was used to identify a potent class of virus-specific inhibitors of the SARS-CoV-2 main protease (Mpro).

TL;DR: In this article, a single-step method for the synthesis of 4-(hetero)aryl substituted thieno[2,3-d]pyrimidines was proposed and the molecular structure of a representative compound was established unambiguously by single crystal X-ray diffraction.

TL;DR: It is reported that oleic acid is an endogenous, metabolic ligand of TLX and open avenues for future therapeutic modulation ofTLX to counteract cognitive and mental decline in aging and diseases associated with decreased neurogenesis.