Lacey E. Dobrolecki

TL;DR: It is shown that type 1 T helper (TH1) cells play a crucial role in vessel normalization, and may be a marker and a determinant of both immune checkpoint blockade and anti-angiogenesis efficacy.

TL;DR: Serially passaged xenografts show biologic consistency with the tumor of origin, are phenotypically stable across multiple transplant generations at the histologic, transcriptomic, proteomic, and genomic levels, and show comparable treatment responses as those observed clinically.

TL;DR: Analysis of cybrids and established breast cancer cell lines showed that metastatic TNBC maintains high levels of ATP through fatty acid β oxidation (FAO) and activates Src oncoprotein through autophosphorylation at Y419, and confirmed the role of mitochondrial FAO in Src activation and metastasis.

TL;DR: Preclinical data show that pharmacologic inhibition of the Notch pathway can reduce BCSCs in breast tumorgraft models and encourage further study of Notch pathways inhibitors in combination with chemotherapy in breast cancer.

TL;DR: This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, and progress toward “credentialing” of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research.