S
Srinivas Sriramula
Researcher at East Carolina University
Publications - 65
Citations - 3688
Srinivas Sriramula is an academic researcher from East Carolina University. The author has contributed to research in topics: Angiotensin II & Renin–angiotensin system. The author has an hindex of 23, co-authored 47 publications receiving 3187 citations. Previous affiliations of Srinivas Sriramula include Louisiana State University & LSU Health Sciences Center New Orleans.
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Journal ArticleDOI
Brain Microglial Cytokines in Neurogenic Hypertension
Peng Shi,Carlos Diez-Freire,Joo Yun Jun,Yanfei Qi,Michael J. Katovich,Qiuhong Li,Srinivas Sriramula,Joseph Francis,Colin Sumners,Mohan K. Raizada +9 more
TL;DR: It is indicated that angiotensin II induced hypertension involves activation of microglia and increases in proinflammatory cytokines in the PVN, which has significant implications on the development of innovative therapeutic strategies for the control of neurogenic hypertension.
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ACE2/ANG-(1–7)/Mas pathway in the brain: the axis of good
TL;DR: The role of the ACE2/ANG-(1-7)/Mas receptor is summarized, focusing on the central nervous system with respect to cardiovascular diseases such as hypertension, chronic heart failure, and stroke, as well as neurological diseases.
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Involvement of Tumor Necrosis Factor-α in Angiotensin II–Mediated Effects on Salt Appetite, Hypertension, and Cardiac Hypertrophy
TL;DR: It is suggested that TNF-α plays a mechanistic role in mediating chronic Ang II–induced effects on salt appetite and blood pressure, as well as on cardiac hypertrophy.
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Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.
Anderson J. Ferreira,Vinayak Shenoy,Yoriko Yamazato,Srinivas Sriramula,Joseph Francis,Lihui Yuan,Ronald K. Castellano,David A. Ostrov,Suk P. Oh,Michael J. Katovich,Mohan K. Raizada +10 more
TL;DR: Conceptual support is provided that activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling PH.
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The Angiotensin-Converting Enzyme 2/Angiogenesis-(1–7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension
Vinayak Shenoy,Anderson J. Ferreira,Yanfei Qi,Rodrigo A. Fraga-Silva,Carlos Diez-Freire,Autumn Dooies,Joo Yun Jun,Srinivas Sriramula,Nithya Mariappan,Dorna Pourang,Changaram S. Venugopal,Joseph Francis,Timothy L. Reudelhuber,Robson A.S. Santos,Jawaharlal M. Patel,Mohan K. Raizada,Michael J. Katovich +16 more
TL;DR: A cardiopulmonary protective role for the ACE2/Ang-(1-7)/Mas axis in the treatment of lung disorders is demonstrated and blockade of the Mas receptor abolished the beneficial effects of Ang-1- 7 against MCT-induced PH.