Showing papers by "Srivari Chandrasekhar published in 2012"
TL;DR: A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields, but these new derivatives have lost most of the neurotrophic activity.
43 citations
TL;DR: In conclusion,aza-Flavanones have been identified as a new class of selective microRNA inhibitors found to arrest cell cycle via a novel cross species microRNA-dependent regulatory pathway interpreting an unexpected link between cell cycle arrest and microRNA mediated control in cancer.
39 citations
TL;DR: The first stereocontrolled and enantiospecific formal synthesis of antiplatelet drug beraprost has been achieved from readily available 1-tetralone.
29 citations
TL;DR: In this article, a review of the total synthesis of gabosines, a family of secondary metabolites containing trihydroxylated cyclohexanone cores, is presented.
28 citations
TL;DR: In this paper, an efficient and eco-friendly method for the synthesis of selected 3-indole derivatives via a copper-catalyzed condensation between indole, aldehydes, and malononitrile in polyethylene glycol was developed.
25 citations
TL;DR: The formal total synthesis of the important toxin fumonisin B 1 was achieved from simple raw materials in a convergent manner in this paper, where the key functionalities were derived from MacMillan α-hydroxylation, sharpless asymmetric dihydroxynylation and ring-closing metathesis.
16 citations
TL;DR: An alternative route for the synthesis of the C14-C26 building block of the anticancer drug eribulin mesylate is described in this article, using Julia-Kocienski olefination between aldehyde 4 and sulfone 5 and a tandem Sharpless asymmetric dihydroxylation/SN2 cyclisation reaction on mesyl compound 3.
15 citations
TL;DR: An organocatalysis strategy has been developed toward the synthesis of O-spiro-C-aryl glycosides with different configurations in the sugar part and it has been extended to the production of the Papulacandin class of compounds.
Abstract: An organocatalysis strategy has been developed toward the synthesis of O-spiro-C-aryl glycosides with different configurations in the sugar part. This strategy has been extended to the synthesis of the Papulacandin class of compounds.
14 citations
TL;DR: In this paper, a diastereocontrolled synthesis of (−)-241D and (−)-isosolenopsin was achieved in 7.7% and 5.3% yields, respectively, using a Barbier-type allylation of a chiral imine and d -proline catalyzed aldol addition reaction of a β-amino aldehyde with acetone as the key steps.
14 citations
TL;DR: The action of irrigant solutions on intra- radicular dentinal surface were evaluated in an in vitro setting using a scanning electron microscope and it was observed that sodium hypochlorite and MTAD produced the cleanest surface and that none of the irrigants were able to produce an ideal preparation of the dentinalsurface when used individually.
Abstract: Aim: The action of irrigant solutions on intra- radicular dentinal surface were evaluated in an in vitro setting using a scanning electron microscope (SEM) and it was observed that sodium hypochlorite and MTAD produced the cleanest surface and that none of the irrigants were able to produce an ideal preparation of the dentinal surface when used individually. The primary objective of endodontic therapy is to achieve a clean, optimal environment in root canals to avoid unsuccessful treatment outcomes. The complexities of the root canal system necessitate the use of irrigating solutions which act on radicular dentin surface, modifying it. The action of irrigants can be beneficial, and yet at the same time, as they modify the surface structure of dentin, they can have an adverse impact on the properties of dentin. The present study was undertaken to assess the effect of various irrigants on the dentinal surface using an SEM. Materials and Methods: Forty-five roots were randomly divided into nine groups (n=5) and prepared by sectioning at the level of cemento-enamel junction (CEJ) and 10 mm from the CEJ and split longitudinally. The dentin surface was prepared and the cemental surfaces were coated with double layer of varnish. The irrigants tested were normal saline, de-ionized water, 17% ethylenediaminetetraacetic acid (EDTA), 5% sodium hypochlorite (NaOCl), 5% NaOCl with ultrasonic agitation, 3% hydrogen peroxide, 2% chlorhexidine (CHX), MTAD, and MTAD with ultrasonic agitation. The prepared samples were placed in the irrigant solution for 3 min, subsequently dehydrated, sputter coated, and observed under SEM. The images were subsequently analyzed for dentinal surface changes. Results: 17% EDTA and MTAD produced the cleanest dentinal surface. Ultrasonic agitation enhanced the effect of irrigants. 5% NaOCl and 3% hydrogen peroxide were efficient at removal of organic debris, but were unable to remove the smear layer. De-ionized water, normal saline, and 2% chlorhexidine were not effective at removing the debris or the smear layer. Conclusion: None of the irrigants individually were able to achieve conditions of an ideal dentinal surface preparation.
12 citations
TL;DR: In this article, the common bicyclic indolizidine core present in several allopumiliotoxins was synthesized by the sequential use of a Crimmins' aldol reaction, an SOCl2-mediated SNi displacement, and an intramolecular nucleophilic acyl substitution (INAS) as the key transformations.
TL;DR: In this paper, the synthesis of 3-hydroxyproline and its derivatives was achieved enantioselectively by employing Sharpless asymmetric epoxidation and reductive cyclization as the key steps.
Abstract: Synthesis of an unusual β-hydroxy-α-amino acid, 3-hydroxyproline, and its derivatives have been achieved enantioselectively by employing Sharpless asymmetric epoxidation and reductive cyclization as the key steps.
TL;DR: In this paper, the preparation of des-hydroxy stachybotrin C is described, and the efficiency of the intermolecular cyclization between the diethyl acetal 19 and phenol 12 leading to the benzopyran moiety 17 is discussed.
Abstract: The preparation of racemic des-hydroxy stachybotrin C is described. Different approaches have been studied. Observations made in the course of the synthesis show the efficiency of the intermolecular cyclization between the diethyl acetal 19 and phenol 12 leading to the benzopyran moiety 17.
TL;DR: A straight forward entry to α,α-dideutero-β-amino esters starting from the corresponding imines and deuterated acetonitrile has been developed involving a two-step process as mentioned in this paper.
TL;DR: The formal total synthesis of the synthetic and stable analogue of prostacyclin, (16 S ) - iloprost, via a convergent synthesis starting from readily available d -glucose was described in this article.
Abstract: The formal total synthesis of the synthetic and stable analogue of prostacyclin, (16 S ) - iloprost is described via a convergent synthesis starting from readily available d -glucose. Julia olefination and the aldol reaction are the key steps involved in the synthesis.
TL;DR: The formal synthesis of (+)-didemniserinolipid B was achieved using Weinreb reaction, Yadav's chiral propargyl alcohol protocol and hydrolytic ketal formation as the key steps as mentioned in this paper.
TL;DR: In this paper, a new versatile synthesis of 3-piperidones was described, starting from amino acids, using an iron carbonyl-mediated intramolecular tandem isomerization-aldolisation reaction.
TL;DR: Stereoselective synthesis of the polyketide fragment commonly present in hoiamide A, B, and C is described using iterative Crimmins aldol reaction as the key reaction.
TL;DR: N-Hydroxyphthalimide and N-hydroxysuccinimide are etherificated in the presence of a catalytic amount of TosOH to give the title products within 1h in <70% yield as discussed by the authors.
Abstract: N-Hydroxyphthalimide and N-hydroxysuccinimide are etherificated in the presence of a catalytic amount of TosOH to give the title products within 1h in <70% yield.
TL;DR: The synthetic approach to the papulacandin aglycone includes the preparation of the known allo and gluco isomers as well as that of the altro isomer as mentioned in this paper.
Abstract: The synthetic approach to the papulacandin aglycone includes the preparation of the known allo and gluco isomers as well as that of the altro isomer.