S
Stefan A. Fattinger
Researcher at Science for Life Laboratory
Publications - 13
Citations - 370
Stefan A. Fattinger is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Biology & Gut Epithelium. The author has an hindex of 6, co-authored 8 publications receiving 152 citations. Previous affiliations of Stefan A. Fattinger include ETH Zurich.
Papers
More filters
Journal ArticleDOI
Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut
Erik Bakkeren,Jana S. Huisman,Jana S. Huisman,Stefan A. Fattinger,Stefan A. Fattinger,Annika Hausmann,Markus Furter,Adrian Egli,Adrian Egli,Emma Slack,Mikael E. Sellin,Sebastian Bonhoeffer,Roland R. Regoes,Médéric Diard,Médéric Diard,Wolf-Dietrich Hardt +15 more
TL;DR: It is concluded that—even without selection for plasmid-encoded resistance genes—small reservoirs of pathogen persisters can foster the spread of promiscuous resistance plasmids in the gut.
Journal ArticleDOI
Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression.
Annika Hausmann,Désirée Böck,Petra Geiser,Petra Geiser,Dorothée L. Berthold,Dorothée L. Berthold,Stefan A. Fattinger,Stefan A. Fattinger,Markus Furter,Judith A Bouman,Manja Barthel-Scherrer,Crispin M. Lang,Erik Bakkeren,Isabel Kolinko,Médéric Diard,Médéric Diard,Dirk Bumann,Emma Slack,Roland R. Regoes,Martin Pilhofer,Mikael E. Sellin,Mikael E. Sellin,Wolf-Dietrich Hardt +22 more
TL;DR: The results highlight the importance of intestinal epithelial NAIP/NLRC4 in blocking bacterial dissemination in vivo, and explain why this constitutes a uniquely evasion-proof defense against the adapted enteropathogen S. Tm.
Journal ArticleDOI
Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice.
Stefan A. Fattinger,Stefan A. Fattinger,Petra Geiser,Pilar Samperio Ventayol,Maria Letizia Di Martino,Markus Furter,Boas Felmy,Erik Bakkeren,Annika Hausmann,Manja Barthel-Scherrer,Ersin Gül,Wolf-Dietrich Hardt,Mikael E. Sellin,Mikael E. Sellin +13 more
TL;DR: In this article, the authors demonstrate that immediate and selective removal of infected enterocytes, by locally acting epithelium-autonomous NAIP/NLRC4, is required to avoid a TNF-driven inflammatory hyper-reaction that otherwise destroys the epithelial barrier.
Journal ArticleDOI
Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium.
Stefan A. Fattinger,Stefan A. Fattinger,Désirée Böck,Maria Letizia Di Martino,Sabrina Deuring,Pilar Samperio Ventayol,Viktor Ek,Markus Furter,Saskia Kreibich,Francesco Bosia,Anna A. Müller-Hauser,Bidong D. Nguyen,Manfred Rohde,Martin Pilhofer,Wolf-Dietrich Hardt,Mikael E. Sellin,Mikael E. Sellin +16 more
TL;DR: Contrary to the prevailing ruffle-model, it is found that absorptive epithelial cell entry in the mouse gut occurs through “discreet-invasion”, which challenges the current model for how S.Tm can enter gut absorption epithelial cells in their intact in vivo context.
Journal ArticleDOI
Epithelial inflammasomes in the defense against Salmonella gut infection.
TL;DR: The gut epithelium prevents bacterial access to the host's tissues and coordinates a number of mucosal defenses, which may enable defense against the challenges imposed by diverse bacterial enteropathogens.