Roland R. Regoes

TL;DR: It is shown that an increase in R0, even when insufficient to generate an epidemic, nonetheless increases the number of subsequently infected individuals and subsequent disease emergence can increase markedly.

TL;DR: There can be profound differences in the microbiological efficacy of antibiotics with identical MICs, as a consequence of differences in pharmacodynamic parameters, such as the steepness of the Hill function and the minimum bacterial net growth rate attained at high antibiotic concentrations.

TL;DR: It is shown that the expression of the genetically identical but phenotypically avirulent subpopulation is essential for the evolutionary stability of virulence in this pathogen, and points to a key role of bistable virulence gene expression in stabilizing cooperative virulence and may lead the way to new approaches for controlling pathogens.

TL;DR: It is shown that a different physical process drives formation of clumps in vivo: IgA-mediated cross-linking enchains daughter cells, preventing their separation after division, and clumping is therefore dependent on growth.

TL;DR: Both fast-cycling and quiescent mouse hematopoietic stem cells (HSCs) can reconstitute lifelong hematoiesis, and HSC cycling status can fluctuate over time in steady state and accelerate upon inflammation.