Stefan Czemmel

TL;DR: This work characterized the first functional characterization of a light-inducible MYB transcription factor controlling flavonol synthesis in fruit, and identified the previously described SG7 domain and an additional sequence motif conserved in several plant MYB factors.

TL;DR: Transient promoter and yeast two-hybrid assays demonstrated that VvMYC1 physically interacts with MYB5a,MYB5b, MYBA1/A2, and MYBPA1 to induce promoters of flavonoid pathway genes involved in anthocyanin and/or proanthocyanidin (PA) synthesis, and transcript levels during berry development correlate with the synthesis ofAnthocyanins and PAs in skins and seeds of berries.

TL;DR: The identification and functional characterization of two stress-inducible R2R3-MYB–type transcription factors from grapevine, termed MYB14 and MYB15, which regulate the stilbene biosynthetic pathway in grapevine are reported.

TL;DR: This review summarizes recent advances in the knowledge of regulatory cascades involved in flavonoid biosynthesis in grapevine with a particular focus on MYB transcription factors as molecular clocks, key regulators and powerful biotechnological tools to identify novel pathway enzymes to optimize flavonoids content and composition in grapes.

TL;DR: Exome-derived mutated HLA ligands appear to be rarely presented in HCCs, inter alia resulting from a low mutational burden as compared to other malignancies such as malignant melanoma, and demand widening the target scope for personalized immunotherapy beyond this limited range of mutated neoepitopes, particularly for malignancy with similar or lower mutationalurden.