Stefania Carobbio

TL;DR: The results indicate that BMP8B is a thermogenic protein that regulates energy balance in partnership with hypothalamic AMPK, and may offer a mechanism to specifically increase energy dissipation by BAT.

TL;DR: Observations define a new role for mitochondrial SIRT4 in the regulation of insulin secretion, which is expressed in islets of Langerhans and colocalizes with insulin-expressing β cells.

TL;DR: It is proposed that the development of successful strategies to target brown and white adipose tissues will depend on investigations that elucidate their developmental origins and cell-type-specific functional regulators.

TL;DR: The mechanisms contributing to adipose tissue (AT) plasticity and function are summarized including characteristics and cellular complexity of the various adipose depots and recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities are discussed.

TL;DR: The results show for the first time that dopamine receptors are expressed in pancreatic beta cells, an effect that could be ascribed to D2-like receptors and point to distal steps in metabolism-secretion coupling.