S
Stefanie M. Novak
Researcher at University of Arizona
Publications - 16
Citations - 592
Stefanie M. Novak is an academic researcher from University of Arizona. The author has contributed to research in topics: Tropomodulin & Actin. The author has an hindex of 10, co-authored 16 publications receiving 454 citations.
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Overview of the Muscle Cytoskeleton.
TL;DR: In this review, the components of striated muscle are highlighted with respect to their interactions, signaling pathways, functions, and connections to disease.
Journal ArticleDOI
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy
Michaela Yuen,Sarah A. Sandaradura,James J. Dowling,James J. Dowling,Alla S. Kostyukova,Natalia Moroz,Kate G. R. Quinlan,Vilma Lotta Lehtokari,Gianina Ravenscroft,Emily J. Todd,Ozge Ceyhan-Birsoy,David S. Gokhin,Jérome Maluenda,Monkol Lek,Monkol Lek,Flora Nolent,Christopher T. Pappas,Stefanie M. Novak,Adele D'Amico,Edoardo Malfatti,Brett Thomas,Brett Thomas,Stacey Gabriel,Namrata Gupta,Mark J. Daly,Mark J. Daly,Biljana Ilkovski,Peter J. Houweling,Peter J. Houweling,Ann E. Davidson,Ann E. Davidson,Lindsay C. Swanson,Catherine A. Brownstein,Vandana Gupta,Livija Medne,Patrick Shannon,Nicole Martin,David P. Bick,Anders Flisberg,Eva Holmberg,Peter Van den Bergh,Pablo Lapunzina,Leigh B. Waddell,Darcée D. Sloboda,Enrico Bertini,David Chitayat,William R. Telfer,Annie Laquerrière,Carol C. Gregorio,Coen A.C. Ottenheijm,Carsten G. Bönnemann,Katarina Pelin,Alan H. Beggs,Yukiko K. Hayashi,Norma B. Romero,Nigel G. Laing,Ichizo Nishino,Carina Wallgren-Pettersson,Judith Melki,Velia M. Fowler,Daniel G. MacArthur,Daniel G. MacArthur,Kathryn N. North,Kathryn N. North,Kathryn N. North,Nigel F. Clarke +65 more
TL;DR: It is demonstrated that mutations in the gene encoding L MOD3 underlie congenital myopathy and demonstrate that LMOD3 is essential for the organization of sarcomeric thin filaments in skeletal muscle.
Journal ArticleDOI
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy: corrigendum
Michaela Yuen,Sarah A. Sandaradura,James J. Dowling,Alla S. Kostyukova,Natalia Moroz,Kate G. R. Quinlan,Vilma-Lotta Lehtokari,Gianina Ravenscroft,Emily J. Todd,Ozge Ceyhan-Birsoy,David S. Gokhin,Jérome Maluenda,Monkol Lek,Flora Nolent,Christopher T. Pappas,Stefanie M. Novak,Adele D'Amico,Edoardo Malfatti,Brett Thomas,Stacey Gabriel,Namrata Gupta,Mark J. Daly,Biljana Ilkovski,Peter J. Houweling,Ann E. Davidson,Lindsay C. Swanson,Catherine A. Brownstein,Vandana Gupta,Livija Medne,Patrick Shannon,Nicole Martin,David P. Bick,Anders Flisberg,Eva Holmberg,Peter Van den Bergh,Pablo Lapunzina,Leigh B. Waddell,Darcée D. Sloboda,Enrico Bertini,David Chitayat,William R. Telfer,Annie Laquerrière,Carol C. Gregorio,Coen A.C. Ottenheijm,Carsten G. Bönnemann,Katarina Pelin,Alan H. Beggs,Yukiko K. Hayashi,Norma B. Romero,Nigel G. Laing,Ichizo Nishino,Carina Wallgren-Pettersson,Judith Melki,Velia M. Fowler,Daniel G. MacArthur,Kathryn N. North,Nigel F. Clarke +56 more
Journal ArticleDOI
Properties of easily releasable myofilaments: are they the first step in myofibrillar protein turnover?
TL;DR: The present study shows that few ERMs could be obtained from the residue after the first removal of ERMs, and the yield of ER Ms from well-washed myofibrils was reduced, probably because some ERMs had been removed by the washing process.
Journal ArticleDOI
Identification of Residues within Tropomodulin-1 Responsible for Its Localization at the Pointed Ends of the Actin Filaments in Cardiac Myocytes
Takehiro Tsukada,Lucy Kotlyanskaya,Robert Huynh,Brinda Desai,Stefanie M. Novak,Andrey V. Kajava,Carol C. Gregorio,Alla S. Kostyukova +7 more
TL;DR: It is demonstrated that the leucine-rich repeat (LRR) fold and the C-terminal helix are necessary for the optimal localization of tropomodulin-1 at thin filament pointed ends, with site 2 acting as the major determinant.