S
Stefano Giulitti
Researcher at University of Padua
Publications - 21
Citations - 6497
Stefano Giulitti is an academic researcher from University of Padua. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 13, co-authored 21 publications receiving 5082 citations. Previous affiliations of Stefano Giulitti include University of Trento.
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Journal ArticleDOI
Role of YAP/TAZ in mechanotransduction
Sirio Dupont,Leonardo Morsut,Mariaceleste Aragona,Elena Enzo,Stefano Giulitti,Michelangelo Cordenonsi,Francesca Zanconato,Jimmy Le Digabel,Mattia Forcato,Silvio Bicciato,Nicola Elvassore,Stefano Piccolo +11 more
TL;DR: YAP/TAZ are identified as sensors and mediators of mechanical cues instructed by the cellular microenvironment and are functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and for survival of endothelial cells regulated by cell geometry.
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A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
Mariaceleste Aragona,Tito Panciera,Andrea Manfrin,Stefano Giulitti,Federica Michielin,Nicola Elvassore,Sirio Dupont,Stefano Piccolo +7 more
TL;DR: It is reported that physical and architectural features of a multicellular sheet inform cells about their proliferative capacity through mechanical regulation of YAP and TAZ, known mediators of Hippo signaling and organ growth.
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YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
Antonio Totaro,Martina Castellan,Giusy Battilana,Francesca Zanconato,Luca Azzolin,Stefano Giulitti,Michelangelo Cordenonsi,Stefano Piccolo +7 more
TL;DR: It is shown that YAP/TAZ regulation by cell shape and rigidity of the extracellular matrix dictates a pivotal SC decision: to remain undifferentiated and grow, or to activate a terminal differentiation programme.
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The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ
Lei Chang,Luca Azzolin,Daniele Di Biagio,Francesca Zanconato,Giusy Battilana,Romy Lucon Xiccato,Mariaceleste Aragona,Stefano Giulitti,Tito Panciera,Alessandro Gandin,Gianluca Sigismondo,Jeroen Krijgsveld,Matteo Fassan,Giovanna Brusatin,Michelangelo Cordenonsi,Stefano Piccolo +15 more
TL;DR: A molecular framework is offered in which mechanical signals that emerge at the tissue level together with genetic lesions activate YAP/TAZ to induce cell plasticity and tumorigenesis.
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Functional differentiation of human pluripotent stem cells on a chip
Giovanni Giuseppe Giobbe,Federica Michielin,Camilla Luni,Stefano Giulitti,Sebastian Martewicz,Sirio Dupont,Annarosa Floreani,Nicola Elvassore +7 more
TL;DR: A robust microfluidics-based approach is described for the differentiation of human pluripotent stem cells directly on a chip for functional phenotypes and responses to temporally defined drug treatments.