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Andrea Manfrin
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 16
Citations - 4675
Andrea Manfrin is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 12 publications receiving 3636 citations. Previous affiliations of Andrea Manfrin include University of Padua.
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Journal ArticleDOI
A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
Mariaceleste Aragona,Tito Panciera,Andrea Manfrin,Stefano Giulitti,Federica Michielin,Nicola Elvassore,Sirio Dupont,Stefano Piccolo +7 more
TL;DR: It is reported that physical and architectural features of a multicellular sheet inform cells about their proliferative capacity through mechanical regulation of YAP and TAZ, known mediators of Hippo signaling and organ growth.
Journal ArticleDOI
Designer matrices for intestinal stem cell and organoid culture
Nikolce Gjorevski,Norman Sachs,Andrea Manfrin,Sonja Giger,Maiia E. Bragina,Paloma Ordóñez-Morán,Hans Clevers,Matthias P. Lutolf +7 more
TL;DR: Modular synthetic hydrogel networks are used to define the key extracellular matrix parameters that govern intestinal stem cell (ISC) expansion and organoid formation, and show that separate stages of the process require different mechanical environments and ECM components.
Journal ArticleDOI
A MicroRNA targeting dicer for metastasis control.
Graziano Martello,Antonio Rosato,Francesco Ferrari,Andrea Manfrin,Michelangelo Cordenonsi,Sirio Dupont,Elena Enzo,Vincenza Guzzardo,Maria Rondina,Thomas Spruce,Anna Parenti,Maria Grazia Daidone,Silvio Bicciato,Stefano Piccolo +13 more
TL;DR: These findings suggest a new pathway by which Dicer inhibition drifts epithelial cancer toward a less-differentiated, mesenchymal fate to foster metastasis, and attenuates miRNA biosynthesis by targeting Dicer, a key component of the miRNA processing machinery.
Journal ArticleDOI
Metabolic control of YAP and TAZ by the mevalonate pathway
Giovanni Sorrentino,Naomi Ruggeri,Valeria Specchia,Michelangelo Cordenonsi,Miguel Mano,Sirio Dupont,Andrea Manfrin,Eleonora Ingallina,Roberta Sommaggio,Silvano Piazza,Antonio Rosato,Stefano Piccolo,Giannino Del Sal +12 more
TL;DR: It is shown that YAP/TAZ activity is controlled by the SREBP/mevalonate pathway, which is required for proliferation and self-renewal of breast cancer cells and reveals an additional layer of YAP-TAZ regulation by metabolic cues.
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Progress and potential in organoid research.
TL;DR: The authors review recent progress in organoid derivation and applications and outline how advances in other disciplines might lead to more physiologically relevant organoids.