N
Nicola Elvassore
Researcher at University of Padua
Publications - 176
Citations - 11619
Nicola Elvassore is an academic researcher from University of Padua. The author has contributed to research in topics: Induced pluripotent stem cell & Biology. The author has an hindex of 42, co-authored 156 publications receiving 9598 citations. Previous affiliations of Nicola Elvassore include ShanghaiTech University & University College London.
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Journal ArticleDOI
Role of YAP/TAZ in mechanotransduction
Sirio Dupont,Leonardo Morsut,Mariaceleste Aragona,Elena Enzo,Stefano Giulitti,Michelangelo Cordenonsi,Francesca Zanconato,Jimmy Le Digabel,Mattia Forcato,Silvio Bicciato,Nicola Elvassore,Stefano Piccolo +11 more
TL;DR: YAP/TAZ are identified as sensors and mediators of mechanical cues instructed by the cellular microenvironment and are functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and for survival of endothelial cells regulated by cell geometry.
Journal ArticleDOI
A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
Mariaceleste Aragona,Tito Panciera,Andrea Manfrin,Stefano Giulitti,Federica Michielin,Nicola Elvassore,Sirio Dupont,Stefano Piccolo +7 more
TL;DR: It is reported that physical and architectural features of a multicellular sheet inform cells about their proliferative capacity through mechanical regulation of YAP and TAZ, known mediators of Hippo signaling and organ growth.
Journal ArticleDOI
Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture.
Giovanni Giuseppe Giobbe,Claire Crowley,Camilla Luni,Sara Campinoti,Sara Campinoti,Moustafa Khedr,Kai Kretzschmar,Martina M. De Santis,Elisa Zambaiti,Federica Michielin,L Meran,L Meran,Qianjiang Hu,Gijs van Son,Luca Urbani,Anna Manfredi,Monica Giomo,Simon Eaton,Davide Cacchiarelli,Vivian S. W. Li,Hans Clevers,Paola Bonfanti,Paola Bonfanti,Nicola Elvassore,Nicola Elvassore,Nicola Elvassore,Paolo De Coppi,Paolo De Coppi +27 more
TL;DR: The derivation of GMP-compliant hydrogels from decellularized porcine small intestine which support formation and growth of human gastric, liver, pancreatic and small intestinal organoids are demonstrated.
Journal ArticleDOI
Electrical stimulation of human embryonic stem cells: cardiac differentiation and the generation of reactive oxygen species.
Elena Serena,Elisa Figallo,Nina Tandon,Christopher Cannizzaro,Sharon Gerecht,Nicola Elvassore,Gordana Vunjak-Novakovic +6 more
TL;DR: Cardiac differentiation in these EBs was evidenced by spontaneous contractions, expression of troponin T and its sarcomeric organization, implying that electrical stimulation plays a role in cardiac differentiation of hESCs, through mechanisms associated with the intracellular generation of ROS.
Journal ArticleDOI
Micro-bioreactor array for controlling cellular microenvironments.
Elisa Figallo,Christopher Cannizzaro,Sharon Gerecht,Jason A. Burdick,Robert Langer,Nicola Elvassore,Gordana Vunjak-Novakovic +6 more
TL;DR: The utility of the micro-bioreactor array for controlled studies of hESCs is established, and correlations between the expression of smooth muscle actin and cell density for three different flow configurations are established.