Y
Yan Jessie Zhang
Researcher at University of Texas at Austin
Publications - 33
Citations - 978
Yan Jessie Zhang is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: RNA polymerase II & Transcription (biology). The author has an hindex of 11, co-authored 33 publications receiving 647 citations.
Papers
More filters
Journal ArticleDOI
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
Shira L. Cramer,Achinto Saha,Jinyun Liu,Surendar Tadi,Stefano Tiziani,Wupeng Yan,Kendra Triplett,Candice Lamb,Susan E. Alters,Scott W. Rowlinson,Yan Jessie Zhang,Michael J. Keating,Peng Huang,John DiGiovanni,George Georgiou,Everett Stone +15 more
TL;DR: It was observed that enzyme-mediated depletion of the serum L-Cys and CSSC pool suppresses the growth of multiple tumors, yet is very well tolerated for prolonged periods, suggesting that cyst(e)inase represents a safe and effective therapeutic modality for inactivating antioxidant cellular responses in a wide range of malignancies.
Journal ArticleDOI
IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions
Chang-Han Lee,Gabrielle Romain,Wupeng Yan,Makiko Watanabe,Wissam Charab,Biliana Todorova,Jiwon Lee,Kendra Triplett,Moses Donkor,Oana I. Lungu,Anja Lux,Nicholas M. Marshall,Margaret A. Lindorfer,Odile Richard-Le Goff,Odile Richard-Le Goff,Bianca Balbino,Bianca Balbino,Bianca Balbino,Tae Hyun Kang,Hidetaka Tanno,George Delidakis,Corrine Alford,Ronald P. Taylor,Falk Nimmerjahn,Navin Varadarajan,Pierre Bruhns,Pierre Bruhns,Yan Jessie Zhang,George Georgiou +28 more
TL;DR: These data highlight the importance of CDCC and CDCP in monoclonal-antibody function and provide an experimental approach for delineating the effect of complement-dependent effector-cell engagement in various therapeutic settings.
Journal ArticleDOI
Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme
Wupeng Yan,Heng Song,Fuhang Song,Yisong Guo,Cheng-Hsuan Wu,Ampon Sae Her,Yi Pu,Shu Wang,Nathchar Naowarojna,Andrew Weitz,Michael P. Hendrich,Catherine E. Costello,Lixin Zhang,Pinghua Liu,Yan Jessie Zhang +14 more
TL;DR: The X-ray crystal structures of FtmOx1 and the binary complexes it forms with either the co-substrate (α-ketoglutarate) or the substrate (fumitremorgin B) help to unravel the novel mechanism for this endoperoxide formation reaction.
Journal ArticleDOI
Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain.
Eric B. Gibbs,Feiyue Lu,Bede Portz,Michael J. Fisher,Brenda P. Medellin,Tatiana N. Laremore,Yan Jessie Zhang,David S. Gilmour,Scott A. Showalter +8 more
TL;DR: Together, context-dependent conformational switches and biased dephosphorylation suggest a mechanism for the selective recruitment of cis-proline-specific regulatory factors and region-specific modulation of the CTD code that may augment gene regulation in developmentally complex organisms.
Journal ArticleDOI
Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain.
Bede Portz,Feiyue Lu,Eric B. Gibbs,Joshua E. Mayfield,M. Rachel Mehaffey,Yan Jessie Zhang,Jennifer S. Brodbelt,Scott A. Showalter,David S. Gilmour +8 more
TL;DR: Surprisingly, it is found that the repetitive CTD of Drosophila melanogaster is structurally heterogeneous, which implicates conserved structural organization, not a precise array of heptad motifs, as important to CTD function.