J
Jack J. Bleesing
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 119
Citations - 6297
Jack J. Bleesing is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 39, co-authored 110 publications receiving 5214 citations. Previous affiliations of Jack J. Bleesing include Science Applications International Corporation & University of Cincinnati Academic Health Center.
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Journal ArticleDOI
Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
Bernice Lo,Kejian Zhang,Wei Lu,Lixin Zheng,Qian Zhang,Chrysi Kanellopoulou,Yu Zhang,Zhiduo Liu,Jill M. Fritz,Rebecca A. Marsh,Ammar Husami,Diane Kissell,Shannon Nortman,Vijaya Chaturvedi,Hilary Haines,Lisa R. Young,Jun Mo,Alexandra H. Filipovich,Jack J. Bleesing,Peter Mustillo,Michael C. Stephens,Cesar M. Rueda,Claire A. Chougnet,Kasper Hoebe,Joshua J McElwee,Jason D. Hughes,Elif Karakoc-Aydiner,Helen F. Matthews,Susan Price,Helen C. Su,V. Koneti Rao,Michael J. Lenardo,Michael B. Jordan +32 more
TL;DR: Patients with an autoimmune disorder caused by deficiency of a protein called LRBA responded dramatically to the drug abatacept, a CTLA4 (cytotoxic T lymphocyte antigen-4)–immunoglobulin fusion drug, and the relationship between the two proteins was revealed: LRBA controls the intracellular trafficking and degradation ofCTLA4.
Journal ArticleDOI
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop.
Joao Bosco Oliveira,Jack J. Bleesing,Umberto Dianzani,Thomas A. Fleisher,Elaine S. Jaffe,Michael J. Lenardo,Frédéric Rieux-Laucat,Richard M. Siegel,Helen C. Su,David T. Teachey,V. Koneti Rao +10 more
TL;DR: It is hoped that harmonizing the diagnosis and classification of ALPS will foster collaborative research and better understanding of the pathogenesis of autoimmune cytopenias and B-cell lymphomas.
Journal ArticleDOI
A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency
Salima Hacein-Bey-Abina,Sung-Yun Pai,H. Bobby Gaspar,Myriam Armant,Charles C. Berry,Stéphane Blanche,Jack J. Bleesing,Johanna Blondeau,Helen de Boer,Karen F. Buckland,Laure Caccavelli,Guilhem Cros,Satiro N. De Oliveira,Karen S. Fernandez,Dongjing Guo,Chad E. Harris,Gregory Hopkins,Leslie Lehmann,Annick Lim,Wendy B. London,Johannes C.M. Van der Loo,Nirav Malani,Frances Male,Punam Malik,M. Angélica Marinovic,Anne Marie McNicol,Despina Moshous,Bénédicte Neven,Matias Oleastro,Capucine Picard,Jerome Ritz,Christine Rivat,Axel Schambach,Kit L. Shaw,Eric A. Sherman,Leslie E. Silberstein,Emmanuelle Six,Fabien Touzot,Alla V. Tsytsykova,Jinhua Xu-Bayford,Christopher Baum,Frederic D. Bushman,Alain Fischer,Donald B. Kohn,Alexandra H. Filipovich,Luigi D. Notarangelo,Marina Cavazzana,David A. Williams,Adrian J. Thrasher +48 more
TL;DR: This modified γ-retrovirus vector was found to retain efficacy in the treatment of SCID-X1 and the long-term effect of this therapy on leukemogenesis remains unknown.
Journal ArticleDOI
Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults.
Sonata Jodele,Stella M. Davies,Adam Lane,Jane C. Khoury,Christopher E. Dandoy,Jens Goebel,Kasiani C. Myers,Michael Grimley,Jack J. Bleesing,Javier El-Bietar,Gregory Wallace,Ranjit S. Chima,Zachary Paff,Benjamin L. Laskin +13 more
TL;DR: It is concluded that severe TMA occurred in 18% of HSCT recipients in this cohort and an algorithm to identify the highest-risk patients who might benefit from prompt clinical interventions is proposed.
Journal ArticleDOI
Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D
Benjamin Chaigne-Delalande,Feng-Yen Li,Feng-Yen Li,Geraldine M. O’Connor,Marshall J. Lukacs,Ping Jiang,Lixin Zheng,Amber N. Shatzer,Matthew Biancalana,Stefania Pittaluga,Helen F. Matthews,Timothy Jancel,Jack J. Bleesing,Rebecca A. Marsh,Taco W. Kuijpers,Kim E. Nichols,Carrie L. Lucas,Sunil Nagpal,Huseyin Mehmet,Helen C. Su,Jeffrey I. Cohen,Gulbu Uzel,Michael J. Lenardo +22 more
TL;DR: It is shown that decreased intracellular free Mg2+ causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8+ T cells and impairs cytolytic responses against EBV.