Stephan Menzel

TL;DR: Twenty-two CD38-specific nanobody families were identified using phage display technology from immunized llamas to represent highly specific tools for modulating the enzymatic activity of CD38 and for diagnostic monitoringCD38-expressing tumors.

TL;DR: The generation of functional nanobodies against the enzymatic CDTa and the heptameric receptor binding subunit CDTb hold promise as new tools for research, diagnosis and therapy of C. difficile associated disease.

TL;DR: Validation of hemopexin (HPX) as a ARTC1-target protein confirmed the functional importance of AR TC1-mediated extracellular arginine ADP-ribosylation at the systems level.

TL;DR: All patients with PLA2R1-associated membranous nephropathy recognize at least two epitope regions in the N- and C-terminals of PLA2r1 at diagnosis, contradicting the hypothesis that PLA2 R1 "epitope spreading" determines the prognosis of membran Mous nephrosy.

TL;DR: Targeting the P2X7 ion channel, a danger sensor for extracellular nucleotides, improves outcomes in models of inflammation, cancer, and brain-diseases, and AAVs may enable modulation of the function of P2x7-expressing immune cells via encoded transgenic RNA or proteins.