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Stephanie Dickinson Caddle
Researcher at Massachusetts Institute of Technology
Publications - 3
Citations - 3011
Stephanie Dickinson Caddle is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Telomerase reverse transcriptase & Telomere. The author has an hindex of 3, co-authored 3 publications receiving 2958 citations.
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Journal ArticleDOI
hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization
Matthew Meyerson,Christopher M. Counter,Elinor Ng Eaton,Leif W. Ellisen,Philipp Steiner,Stephanie Dickinson Caddle,Liuda Ziaugra,Roderick L. Beijersbergen,Michael J. Davidoff,Qingyun Liu,Silvia Bacchetti,Daniel A. Haber,Robert A. Weinberg +12 more
TL;DR: The cloning of a human gene, hEST2, that shares significant sequence similarity with the telomerase catalytic subunit genes of lower eukaryotes is reported, suggesting that the induction of hEST 2 mRNA expression is required for the telomersase activation that occurs during cellular immortalization and tumor progression.
Journal ArticleDOI
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
Christopher M. Counter,William C. Hahn,Wenyi Wei,Stephanie Dickinson Caddle,Roderick L. Beijersbergen,Peter M. Lansdorp,John M. Sedivy,Robert A. Weinberg +7 more
TL;DR: It is shown that ectopic expression of the telomerase catalytic subunit (human telomersase reverse transcriptase or hTERT) and subsequent activation of telomer enzyme can allow postsenescent cells to proliferate beyond crisis, the last known proliferative blockade to cellular immortality.
Journal ArticleDOI
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase
Christopher M. Counter,Matthew Meyerson,Matthew Meyerson,Elinor Ng Eaton,Leif W. Ellisen,Stephanie Dickinson Caddle,Daniel A. Haber,Robert A. Weinberg +7 more
TL;DR: It is concluded that synthesis of the hTERT telomerase subunit represents the rate-limiting determinant of telomer enzyme activity in these cells and that this protein, once expressed, becomes part of the functional telomersase holoenzyme.