Stephanie L. Sarbanes

TL;DR: Human ADAR1 regulates sensing of self versus nonself RNA, allowing pathogen detection while avoiding autoinflammation, and knockout neurons exhibited MDA5 (dsRNA sensor)-dependent spontaneous interferon production, PKR activation, and cell death.

TL;DR: It is shown that intrinsically expressed ISGs protect stem cells against viral infection, demonstrating the in vivo importance of intrinsic ISG expression for protecting stem cells and their differentiation potential during viral infection.

TL;DR: It is demonstrated that elevated H NRNPC is essential for the proliferative ability of two breast cancer cell lines and reducing HNRNPC results in the accumulation of short Alu‐derived dsRNAs that bind RNA receptor RIG‐I and stimulate the production of IFN, a cytokine with known antiproliferative activity.

TL;DR: In this paper, the authors performed a gene-trap screen in haploid cells to identify host factors for adenovirus (AdV), a DNA virus that can cause severe respiratory illness in immune-compromised individuals.

TL;DR: Sarbanes et al. as mentioned in this paper discuss microtubule-severing enzymes, highlighting their shared structure and mechanism and the diversity of processes in which they participate, and propose a method to detect the presence of microtubules.