Yaomei Wang

TL;DR: It is shown that intrinsically expressed ISGs protect stem cells against viral infection, demonstrating the in vivo importance of intrinsic ISG expression for protecting stem cells and their differentiation potential during viral infection.

TL;DR: In this article, the identity of EBI macrophages has thus far remained elusive, but it is known that Epor-eGFP is essential for erythropoiesis and Epor is expressed in numerous nonerythroid cells.

TL;DR: It is shown here that TET2 and TET3 but not TET1 are expressed in human erythroid cells, and the role of these proteins in erythropoiesis is explored, to provide new insights into their role in regulating human ERYthroid differentiation at distinct stages of development.

TL;DR: It is shown that TET2 deficiency leads initially to stem cell factor-dependent hyperproliferation and impaired differentiation of human colony-forming unit-erythroid (CFU-E) cells, which were reversed by a c-Kit inhibitor, and previously unknown mechanisms by which deficiency of TET1 contributes to ineffective erythropoiesis are uncovered.

TL;DR: It is Documented that SF3B1 knockdown in human CD34+ cells leads to increased apoptosis and cell cycle arrest of early-stage erythroid cells and generation of abnormally nucleated late-Stage erythroblasts and these findings have implications for improved understanding of ineffective erythropoiesis in MDS patients with SF3 B1 mutations.