E
Eric Le Cam
Researcher at Université Paris-Saclay
Publications - 96
Citations - 4667
Eric Le Cam is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: DNA & DNA repair. The author has an hindex of 34, co-authored 87 publications receiving 4209 citations. Previous affiliations of Eric Le Cam include Institut Gustave Roussy & University of Paris-Sud.
Papers
More filters
Journal ArticleDOI
The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.
Xavier Veaute,Josette Jeusset,Christine Soustelle,Stephen C. Kowalczykowski,Eric Le Cam,Francis Fabre +5 more
TL;DR: It is shown that DNA strand exchange mediated in vitro by Rad51 is inhibited by Srs2, and that SRS2 disrupts Rad51 filaments formed on single-stranded DNA, providing an explanation for the anti-recombinogenic role of Srs1 in vivo and highlighting a previously unknown mechanism for recombination control.
Journal ArticleDOI
UvrD helicase, unlike Rep helicase, dismantles RecA nucleoprotein filaments in Escherichia coli
Xavier Veaute,Stéphane Delmas,Marjorie Selva,Josette Jeusset,Eric Le Cam,Ivan Matic,Francis Fabre,Marie-Agnès Petit +7 more
TL;DR: It is shown that UvrD, but not Rep, directly prevents homologous recombination in vivo, and evidence that RecA contributes to toxicity in the rep uvrD mutant is provided.
Journal ArticleDOI
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer.
Guy Berchem,Muhammad Zaeem Noman,Manon Bosseler,Jérôme Paggetti,Sonia Baconnais,Eric Le Cam,Arash Nanbakhsh,Etienne Moussay,Fathia Mami-Chouaib,Bassam Janji,Salem Chouaib +10 more
TL;DR: This is the first study to show that hypoxic tumor cells by secreting MVs can educate NK cells and decrease their antitumor immune response, and highlights the existence of a novel mechanism of immune suppression mediated by hypoxic TD-MVs.
Journal ArticleDOI
A Key Presynaptic Role in Transformation for a Widespread Bacterial Protein: DprA Conveys Incoming ssDNA to RecA
Isabelle Mortier-Barrière,Marion Velten,Pauline Dupaigne,Nicolas Mirouze,Nicolas Mirouze,Olivier Piétrement,Stephen McGovern,Gwennaele Fichant,Bernard Martin,Philippe Noirot,Eric Le Cam,Patrice Polard,Jean-Pierre Claverys +12 more
TL;DR: It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation, and it is shown that while the Escherichia coli ssDNA-binding protein SSB limits access of RecA to ssDNA, DPRA lowers this barrier.
Journal ArticleDOI
Adsorption of DNA to mica mediated by divalent counterions: a theoretical and experimental study.
David Pastré,Olivier Piétrement,Stéphane Fusil,Fabrice Landousy,Josette Jeusset,Marie-Odile David,Loic Hamon,Eric Le Cam,Alain Zozime +8 more
TL;DR: A model suggests that DNA attraction is due to the sharing of the DNA and mica counterions, and it is explained how a reversible binding of theDNA molecules can be obtained with a pretreated mica surface.