S
Stephen D. Smith
Researcher at University of Chicago
Publications - 139
Citations - 8111
Stephen D. Smith is an academic researcher from University of Chicago. The author has contributed to research in topics: Chromosomal translocation & Internal medicine. The author has an hindex of 44, co-authored 116 publications receiving 7920 citations. Previous affiliations of Stephen D. Smith include College of Health Sciences, Bahrain & University of Illinois at Chicago.
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Journal ArticleDOI
Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
TL;DR: The results suggest that t(14;18) translocations alter expression of the bcl-2 gene both by transcriptional activation and by abnormal posttranscriptional regulation of bCl-2 mRNA.
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Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
Jamison Nourse,Julia D. Mellentin,Naomi Galili,Joyce Wilkinson,Eric J. Stanbridge,Stephen D. Smith,Michael L. Cleary +6 more
TL;DR: Identical E2A-prl mRNA junctions were detected by PCR in three t(1;19)-carrying cell lines, indicating that the fusion transcripts and predicted chimeric protein are a consistent feature of this translocation.
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Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
S Ziemin-van der Poel,Norah R. McCabe,H J Gill,R. Espinosa,Y D Patel,A Harden,Peter M. Rubinelli,Stephen D. Smith,Michelle M. LeBeau,Janet Rowley +9 more
TL;DR: This gene MLL (myeloid/lymphoid, or mixed-lineage, leukemia) is named after a transcription unit that spans the breakpoint junctions of the 4;11, 9:11, and 11;19 translocations and two other transcripts that are upregulated in the RS4;11 cell line are described.
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Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines
Manuel O. Diaz,S Ziemin,M M Le Beau,Paula M. Pitha,Stephen D. Smith,Robert R. Chilcote,Janet Rowley +6 more
TL;DR: Evidence is presented of the homozygous deletion of the interferon genes in neoplastic hematopoietic cell lines and primary leukemia cells in the presence or absence of chromosomal deletions that are detectable at the level of the light microscope.
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lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif
TL;DR: A transcription unit at chromosome band 19p13 that lies at the site of a chromosomal translocation breakpoint in T cell acute lymphoblastic leukemia is characterized, suggesting that other proteins containing similar DNA binding motifs may also be involved with neoplastic transformation in various cellular lineages.