S
Steven J. Van Dyken
Researcher at Washington University in St. Louis
Publications - 43
Citations - 4149
Steven J. Van Dyken is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Immune system & Innate lymphoid cell. The author has an hindex of 19, co-authored 33 publications receiving 3308 citations. Previous affiliations of Steven J. Van Dyken include University of California, San Francisco & University of California, San Diego.
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Journal ArticleDOI
Type 2 innate lymphoid cells control eosinophil homeostasis
Jesse C. Nussbaum,Steven J. Van Dyken,Jakob von Moltke,Laurence E. Cheng,Alexander Mohapatra,Ari B. Molofsky,Emily E. Thornton,Matthew F. Krummel,Ajay Chawla,Hong-Erh Liang,Richard M. Locksley +10 more
TL;DR: It is shown that serum IL-5 levels are maintained by long-lived type 2 innate lymphoid cells (ILC2) resident in peripheral tissues, and this dissociated regulation can be tuned by nutrient intake and central circadian rhythms.
Journal ArticleDOI
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
Ari B. Molofsky,Jesse C. Nussbaum,Hong-Erh Liang,Steven J. Van Dyken,Laurence E. Cheng,Alexander Mohapatra,Ajay Chawla,Richard M. Locksley +7 more
TL;DR: Innate lymphoid type 2 cells maintain eosinophils and alternatively activated macrophages in visceral fat via the production of IL-5 and IL-13.
Journal ArticleDOI
Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease
TL;DR: Recent advances in the understanding of IL-4- and IL-13-mediated alternatively activated macrophages and type 2 immune responses have led to an expanded appreciation for functions of these cells beyond immunity, including maintenance of physiologic homeostasis and tissue repair.
Journal ArticleDOI
InterleuKin-33 And Interferon-Γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation During Immune Perturbation
Ari B. Molofsky,Frédéric Van Gool,Hong-Erh Liang,Steven J. Van Dyken,Jesse C. Nussbaum,Jinwoo Lee,Jeffrey A. Bluestone,Richard M. Locksley +7 more
TL;DR: Interleukin-33 mediates activation of ILC2s and Treg cells in resting adipose tissue, but also after helminth infection or treatment with IL-2, and IFN-γ suppresses this pathway, likely to promote inflammatory responses and divert metabolic resources necessary to protect the host.
Journal ArticleDOI
Tissue signals imprint ILC2 identity with anticipatory function.
Roberto R. Ricardo-Gonzalez,Steven J. Van Dyken,Steven J. Van Dyken,Christoph Schneider,Jinwoo Lee,Jesse C. Nussbaum,Hong-Erh Liang,Dedeepya Vaka,Walter L. Eckalbar,Ari B. Molofsky,David J. Erle,Richard M. Locksley +11 more
TL;DR: Tissue-specific imprinting dictates the activating receptors ILC2s express, even in germ-free mice, and it is shown that endogenous, tissue-derived signals drive the maturation of I LC2 subsets by controlling expression of distinct patterns of activating receptors, thus anticipating tissue-specific perturbations occurring later in life.