Type 2 innate lymphoid cells control eosinophil homeostasis
Jesse C. Nussbaum,Steven J. Van Dyken,Jakob von Moltke,Laurence E. Cheng,Alexander Mohapatra,Ari B. Molofsky,Emily E. Thornton,Matthew F. Krummel,Ajay Chawla,Hong-Erh Liang,Richard M. Locksley +10 more
TLDR
It is shown that serum IL-5 levels are maintained by long-lived type 2 innate lymphoid cells (ILC2) resident in peripheral tissues, and this dissociated regulation can be tuned by nutrient intake and central circadian rhythms.Abstract:
Eosinophils are specialized myeloid cells associated with allergy and helminth infections. Blood eosinophils demonstrate circadian cycling, as described over 80 years ago, and are abundant in the healthy gastrointestinal tract. Although a cytokine, interleukin (IL)-5, and chemokines such as eotaxins mediate eosinophil development and survival, and tissue recruitment, respectively, the processes underlying the basal regulation of these signals remain unknown. Here we show that serum IL-5 levels are maintained by long-lived type 2 innate lymphoid cells (ILC2) resident in peripheral tissues. ILC2 cells secrete IL-5 constitutively and are induced to co-express IL-13 during type 2 inflammation, resulting in localized eotaxin production and eosinophil accumulation. In the small intestine where eosinophils and eotaxin are constitutive, ILC2 cells co-express IL-5 and IL-13; this co-expression is enhanced after caloric intake. The circadian synchronizer vasoactive intestinal peptide also stimulates ILC2 cells through the VPAC2 receptor to release IL-5, linking eosinophil levels with metabolic cycling. Tissue ILC2 cells regulate basal eosinophilopoiesis and tissue eosinophil accumulation through constitutive and stimulated cytokine expression, and this dissociated regulation can be tuned by nutrient intake and central circadian rhythms.read more
Citations
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Journal ArticleDOI
The biology of innate lymphoid cells
David Artis,Hergen Spits +1 more
TL;DR: This work summarizes the studies that formally identified innate lymphoid cells and highlights their emerging roles in controlling tissue homeostasis in the context of infection, chronic inflammation, metabolic disease and cancer.
Journal ArticleDOI
Innate Lymphoid Cells: 10 Years On.
Eric Vivier,David Artis,Marco Colonna,Andreas Diefenbach,James P. Di Santo,James P. Di Santo,Gérard Eberl,Gérard Eberl,Shigeo Koyasu,Richard M. Locksley,Andrew N. J. McKenzie,Reina E. Mebius,Fiona Powrie,Hergen Spits +13 more
TL;DR: The advances in ILC biology over the past decade are distill the advances to refine the nomenclature of ILCs and highlight the importance of I LCs in tissue homeostasis, morphogenesis, metabolism, repair, and regeneration.
Journal ArticleDOI
Regional specialization within the intestinal immune system
TL;DR: The anatomical and physiological distinctions that are observed in the small and large intestines are detailed, and it is suggested how these may account for the diversity in the immune apparatus that is seen throughout the intestine.
Journal ArticleDOI
Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.
Christoph S.N. Klose,Christoph S.N. Klose,Melanie Flach,Melanie Flach,Luisa Möhle,Leif Rogell,Leif Rogell,Leif Rogell,Thomas Hoyler,Thomas Hoyler,Karolina Ebert,Karolina Ebert,Carola Fabiunke,Carola Fabiunke,Dietmar Pfeifer,Veronika Sexl,Diogo Fonseca-Pereira,Rita G. Domingues,Henrique Veiga-Fernandes,Sebastian J. Arnold,Meinrad Busslinger,Ildiko Rita Dunay,Yakup Tanriver,Andreas Diefenbach +23 more
TL;DR: Interestingly, the CHILP differentiated into ILC2 and ILC3 lineages, but not into conventional natural killer cells that have been considered an ILC1 subset, presenting evidence for a new ILC lineage that protects barrier surfaces against intracellular infections.
Journal ArticleDOI
Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit
TL;DR: It is shown that tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the resting lamina propria in mice, and comprise a response circuit that mediates epithelial remodelling associated with type 2 immunity in the small intestine, and perhaps at other mucosal barriers populated by these cells.
References
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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill,See Heng Wong,Agustin Bellosi,Robin J. Flynn,Maria Daly,Theresa K. A. Langford,Christine Bucks,Colleen M. Kane,Padraic G. Fallon,Richard Pannell,Helen E. Jolin,Andrew N.J. McKenzie +11 more
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TL;DR: In this article, a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose tissues in the peritoneal cavity was reported. But these cells do not express lineage (Lin) markers but do express c-Kit, Sca-1 (also known as Ly6a), IL7R and IL33R.
Journal ArticleDOI
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
Jenny Mjösberg,Sara Trifari,Sara Trifari,Natasha K Crellin,Natasha K Crellin,Charlotte P. Peters,Cornelis M. van Drunen,Berber Piet,Wytske Fokkens,Tom Cupedo,Hergen Spits +10 more
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Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
April E. Price,Hong-Erh Liang,Brandon M. Sullivan,R. Lee Reinhardt,Chris J. Eisley,David J. Erle,Richard M. Locksley +6 more
TL;DR: In this paper, lineage-negative IL-25 and IL-33 responsive cells are found to be widely distributed in tissues of the mouse and are particularly prevalent in mesenteric lymph nodes, spleen, and liver.
Journal ArticleDOI
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
Ari B. Molofsky,Jesse C. Nussbaum,Hong-Erh Liang,Steven J. Van Dyken,Laurence E. Cheng,Alexander Mohapatra,Ajay Chawla,Richard M. Locksley +7 more
TL;DR: Innate lymphoid type 2 cells maintain eosinophils and alternatively activated macrophages in visceral fat via the production of IL-5 and IL-13.
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