다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

On September 14, 2015 at 09:50:45 UTC the two detectors of the Laser Interferometer Gravitational-Wave Observatory simultaneously observed a transient gravitational-wave signal. The signal sweeps upwards in frequency from 35 to 250 Hz with a peak gravitational-wave strain of 1.0×10(-21). It matches the waveform predicted by general relativity for the inspiral and merger of a pair of black holes and the ringdown of the resulting single black hole. The signal was observed with a matched-filter signal-to-noise ratio of 24 and a false alarm rate estimated to be less than 1 event per 203,000 years, equivalent to a significance greater than 5.1σ. The source lies at a luminosity distance of 410(-180)(+160)  Mpc corresponding to a redshift z=0.09(-0.04)(+0.03). In the source frame, the initial black hole masses are 36(-4)(+5)M⊙ and 29(-4)(+4)M⊙, and the final black hole mass is 62(-4)(+4)M⊙, with 3.0(-0.5)(+0.5)M⊙c(2) radiated in gravitational waves. All uncertainties define 90% credible intervals. These observations demonstrate the existence of binary stellar-mass black hole systems. This is the first direct detection of gravitational waves and the first observation of a binary black hole merger.

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The Observation of Gravitational Waves from a Binary Black Hole Merger

We explore in this chapter questions of existence and uniqueness for solutions to stochastic differential equations and offer a study of their properties. This endeavor is really a study of diffusion processes. Loosely speaking, the term diffusion is attributed to a Markov process which has continuous sample paths and can be characterized in terms of its infinitesimal generator.

Stochastic Differential Equations

Quasinormal modes are eigenmodes of dissipative systems. Perturbations of classical gravitational backgrounds involving black holes or branes naturally lead to quasinormal modes. The analysis and classification of the quasinormal spectra require solving non-Hermitian eigenvalue problems for the associated linear differential equations. Within the recently developed gauge-gravity duality, these modes serve as an important tool for determining the near-equilibrium properties of strongly coupled quantum field theories, in particular their transport coefficients, such as viscosity, conductivity and diffusion constants. In astrophysics, the detection of quasinormal modes in gravitational wave experiments would allow precise measurements of the mass and spin of black holes as well as new tests of general relativity. This review is meant as an introduction to the subject, with a focus on the recent developments in the field.

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Quasinormal modes of black holes and black branes

The idea of stable, localized bundles of energy has strong appeal as a model for particles. In the 1950s, John Wheeler envisioned such bundles as smooth configurations of electromagnetic energy that he called geons, but none were found. Instead, particle-like solutions were found in the late 1960s with the addition of a scalar field, and these were given the name boson stars. Since then, boson stars find use in a wide variety of models as sources of dark matter, as black hole mimickers, in simple models of binary systems, and as a tool in finding black holes in higher dimensions with only a single Killing vector. We discuss important varieties of boson stars, their dynamic properties, and some of their uses, concentrating on recent efforts.

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Dynamical boson stars

The idea of stable, localized bundles of energy has strong appeal as a model for particles. In the 1950s John Wheeler envisioned such bundles as smooth configurations of electromagnetic energy that he called {\em geons}, but none were found. Instead, particle-like solutions were found in the late 1960s with the addition of a scalar field, and these were given the name {\em boson stars}. Since then, boson stars find use in a wide variety of models as sources of dark matter, as black hole mimickers, in simple models of binary systems, and as a tool in finding black holes in higher dimensions with only a single killing vector. We discuss important varieties of boson stars, their dynamic properties, and some of their uses, concentrating on recent efforts.

/pdf/dynamical-boson-stars-1uh9ns5l5s.pdf

Dynamical Boson Stars

We study the merger of binary neutron stars using different realistic, microphysical nuclear equations of state, as well as incorporating magnetic field and neutrino cooling effects. In particular, we concentrate on the influence of the equation of state on the gravitational wave signature and also on its role, in combination with cooling and electromagnetic effects, in determining the properties of the hypermassive neutron star resulting from the merger, the production of neutrinos, and the characteristics of ejecta from the system. The ejecta we find are consistent with other recent studies that find soft equations of state produce more ejecta than stiffer equations of state. Moreover, the degree of neutron richness increases for softer equations of state. In light of reported kilonova observations (associated to GRB 130603B and GRB 060614) and the discovery of relatively low abundances of heavy, radioactive elements in deep sea deposits (with respect to possible production via supernovae), we speculate that a soft equation of state (EOS) might be preferred—because of its significant production of sufficiently neutron rich ejecta—if such events are driven by binary neutron star mergers. We also find that realistic magnetic field strengths, obtained with a subgrid model tuned to capture magnetic amplification via the Kelvin-Helmholtz instability at merger, are generally too weak to affect the gravitational wave signature postmerger within a time scale of ≈10  ms but can have subtle effects on the postmerger dynamics.

Effects of the microphysical Equation of State in the mergers of magnetized Neutron Stars With Neutrino Cooling

The coalescence of supermassive black holes--a natural outcome when galaxies merge--should produce gravitational waves and would likely be associated with energetic electromagnetic events. We have studied the coalescence of such binary black holes within an external magnetic field produced by the expected circumbinary disk surrounding them. Solving the Einstein equations to describe black holes interacting with surrounding plasma, we present numerical evidence for possible jets driven by these systems. Extending the process described by Blandford and Znajek for a single, spinning black hole, the picture that emerges suggests that the electromagnetic field extracts energy from the orbiting black holes, which ultimately merge and settle into the standard Blandford-Znajek scenario. Emissions along these jets could potentially be observable at large distances.

Dual Jets from Binary Black Holes

We investigate the influence of magnetic fields upon the dynamics of, and resulting gravitational waves from, a binary neutron-star merger in full general relativity coupled to ideal magnetohydrodynamics. We consider two merger scenarios: one where the stars have aligned poloidal magnetic fields and one without. Both mergers result in a strongly differentially rotating object. In comparison to the nonmagnetized scenario, the aligned magnetic fields delay the full merger of the stars. During and after merger we observe phenomena driven by the magnetic field, including Kelvin-Helmholtz instabilities in shear layers, winding of the field lines, and transition from poloidal to toroidal magnetic fields. These effects not only mediate the production of electromagnetic radiation, but also can have a strong influence on the gravitational waves. Thus, there are promising prospects for studying such systems with both types of waves.

Steven L. Liebling

Papers

Dynamical boson stars

Dynamical Boson Stars

Effects of the microphysical Equation of State in the mergers of magnetized Neutron Stars With Neutrino Cooling

Dual Jets from Binary Black Holes

Magnetized Neutron-Star Mergers and Gravitational-Wave Signals