S
Steven T. Leach
Researcher at University of New South Wales
Publications - 121
Citations - 4553
Steven T. Leach is an academic researcher from University of New South Wales. The author has contributed to research in topics: Inflammatory bowel disease & Calprotectin. The author has an hindex of 35, co-authored 119 publications receiving 3906 citations. Previous affiliations of Steven T. Leach include Boston Children's Hospital.
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Journal ArticleDOI
Severe pediatric ulcerative colitis: a prospective multicenter study of outcomes and predictors of response.
Dan Turner,David R. Mack,Neal Leleiko,Thomas D. Walters,Krista Uusoue,Steven T. Leach,Andrew S. Day,Wallace Crandall,Mark S. Silverberg,James Markowitz,Anthony R. Otley,David J. Keljo,Petar Mamula,Subra Kugathasan,Jeffrey S. Hyams,Anne M. Griffiths +15 more
TL;DR: The PUCAI, calculated on days 3 and 5 of steroid therapy, can identify patients requiring salvage therapy and infliximab is an effective therapy in steroid-refractory pediatric UC.
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Measurement of fecal calprotectin improves monitoring and detection of recurrence of Crohn's disease after surgery
Emily K Wright,Emily K Wright,Michael A. Kamm,Michael A. Kamm,Peter De Cruz,Peter De Cruz,Amy L. Hamilton,Amy L. Hamilton,Kathryn J. Ritchie,Efrosinia O. Krejany,Steven T. Leach,Alexandra Gorelik,Danny Liew,Lani Prideaux,Lani Prideaux,Ian C. Lawrance,Ian C. Lawrance,Jane M. Andrews,Jane M. Andrews,Peter A. Bampton,Peter A. Bampton,Simon Jakobovits,Timothy H. Florin,Peter R. Gibson,H.S. Debinski,Finlay A. Macrae,Finlay A. Macrae,Douglas Samuel,Ian Kronborg,Graham L. Radford-Smith,Warwick Selby,M. Johnston,Rodney Woods,P. Ross Elliott,Sally Bell,Steven J. Brown,William Connell,Andrew S. Day,Paul V. Desmond,Paul V. Desmond,Richard B. Gearry +40 more
TL;DR: In this analysis of data from a prospective clinical trial, FC measurement has sufficient sensitivity and NPV values to monitor for CD recurrence after intestinal resection and its predictive value might be used to identify patients most likely to relapse.
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Serum and mucosal S100 proteins, calprotectin (S100A8/S100A9) and S100A12, are elevated at diagnosis in children with inflammatory bowel disease.
Steven T. Leach,Zheng Yang,Isabella Messina,Changjie Song,Carolyn L. Geczy,Anne M. Cunningham,Andrew S. Day +6 more
TL;DR: Serum calprotectin and S100A12 are increased in children with IBD and indicate disease activity, and Elevated levels of these proteins are present in the colonic mucosa and may contribute to the pathogenesis of IBD.
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Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohn's disease
Si Ming Man,Li Zhang,Andrew S. Day,Andrew S. Day,Steven T. Leach,Daniel A. Lemberg,Hazel M. Mitchell +6 more
TL;DR: Investigation into the role of these non‐jejuni Campylobacter species in the initiation of human IBD is clearly a priority given the strengthening evidence for a significantly higher prevalence of C. concisus in pediatric CD.
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Defensins and inflammation: the role of defensins in inflammatory bowel disease.
TL;DR: It is less clear whether defensin deficiency is implicated in the pathogenesis of IBD or is a consequence of the disease process, although the aim of this article is to review the current knowledge of defensins in IBD and discuss their potential role.