S
Steven W. Kerrigan
Researcher at Royal College of Surgeons in Ireland
Publications - 62
Citations - 3193
Steven W. Kerrigan is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 25, co-authored 56 publications receiving 2699 citations.
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Journal ArticleDOI
Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A.
Louise O’Brien,Steven W. Kerrigan,Gideon Kaw,Michael S. Hogan,José R. Penadés,David Litt,Desmond J. Fitzgerald,Timothy J. Foster,Dermot Cox +8 more
TL;DR: S. aureus has multiple mechanisms for stimulating platelet aggregation, and functional redundancy suggests that this phenomenon may be important in the pathogenesis of invasive diseases such as infective endocarditis.
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Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation.
TL;DR: The variety of interactions between platelets and bacteria is reviewed, and the potential for inhibiting these interactions in diseases such as infective endocarditis and sepsis is looked at.
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Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions
Nicola Kavanagh,Emily J. Ryan,Amro Widaa,Gillian Sexton,Jérôme P. Fennell,Sadhbh O'Rourke,Kevin C. Cahill,Cathal J. Kearney,Fergal J. O'Brien,Fergal J. O'Brien,Steven W. Kerrigan +10 more
TL;DR: Osteomyelitis is an inflammatory bone disease that is caused by an infecting microorganism and leads to progressive bone destruction and loss, and staphylococcal infections are becoming an increasing global concern.
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A serine‐rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb
TL;DR: It is shown that a high molecular weight glycoprotein of S. sanguis mediates adhesion to glycocalacin, which helps to understand the mechanisms by which the organism might colonize platelet‐fibrin vegetations.
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Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation.
Michael F. Byrne,Michael F. Byrne,Steven W. Kerrigan,Paul A. Corcoran,John Atherton,Frank E. Murray,Desmond J. Fitzgerald,Dermot Cox +7 more
TL;DR: The interaction with platelets appeared to be mediated by vWF because platelet aggregation was blocked by an antibody to vWF, and a strain of H. pylori that induced Platelet aggregation bound vWF to a greater extent than a nonaggregating strain.