S
Subhadra V. Nandula
Researcher at Columbia University
Publications - 35
Citations - 3597
Subhadra V. Nandula is an academic researcher from Columbia University. The author has contributed to research in topics: Gene & Cytogenetics. The author has an hindex of 19, co-authored 35 publications receiving 3345 citations. Previous affiliations of Subhadra V. Nandula include University of New Mexico & Columbia University Medical Center.
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Journal ArticleDOI
Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma
Mara Compagno,Wei Keat Lim,Adina Grunn,Subhadra V. Nandula,Manisha Brahmachary,Qiong Shen,Francesco Bertoni,Maurilio Ponzoni,Marta Scandurra,Andrea Califano,Govind Bhagat,Amy Chadburn,Riccardo Dalla-Favera,Laura Pasqualucci +13 more
TL;DR: The results demonstrate that NF-κB activation in DLBCL is caused by genetic lesions affecting multiple genes, the loss or activation of which may promote lymphomagenesis by leading to abnormally prolonged NF-σκB responses.
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Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma
Laura Pasqualucci,Mara Compagno,Jane Houldsworth,Stefano Monti,Adina Grunn,Subhadra V. Nandula,Jon C. Aster,V. V. V. S. Murty,Margaret A. Shipp,Riccardo Dalla-Favera +9 more
TL;DR: Findings point to a role for BLIMP1 as a tumor suppressor gene, whose inactivation may contribute to lymphomagenesis by blocking post–GC differentiation of B cells toward plasma cells, and suggest that the same gene is inactivated by epigenetic mechanisms in an additional large number of cases.
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Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
Giorgio Cattoretti,Laura Pasqualucci,Gianna Ballon,Wayne Tam,Subhadra V. Nandula,Qiong Shen,Tongwei Mo,Vundavalli V. Murty,Riccardo Dalla-Favera +8 more
TL;DR: The engineered mice engineered in this work express BCL6 constitutively in B cells by mimicking a chromosomal translocation found in human DLBCL and develop a lymphoproliferative syndrome that culminates with the development of lymphomas displaying features typical of human DLBS.
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Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: Potential role in progression
Luigi Scotto,Gopeshwar Narayan,Subhadra V. Nandula,Hugo Arias-Pulido,Shivakumar Subramaniyam,Achim Schneider,Andreas M. Kaufmann,Jason D. Wright,Bhavana Pothuri,Mahesh M. Mansukhani,Vundavalli V. Murty +10 more
TL;DR: The findings implicate a role for these genes in CC tumorigenesis, represent an important step toward the development of clinically significant biomarkers, and form a framework for testing as molecular therapeutic targets.
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The NF-κB negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas
Urban Novak,Andrea Rinaldi,Ivo Kwee,Subhadra V. Nandula,Paola M.V. Rancoita,Mara Compagno,Michaela Cerri,Davide Rossi,Vundavalli V. Murty,Emanuele Zucca,Gianluca Gaidano,Riccardo Dalla-Favera,Laura Pasqualucci,Govind Bhagat,Francesco Bertoni +14 more
TL;DR: A20 inactivation by either somatic mutation and/or deletion represents a common genetic aberration across all MZL subtypes, which may contribute to lymphomagenesis by inducing constitutive NF-kappaB activation.