Sui Zhang

TL;DR: Cardiomyocyte-specific deletion of Top2b (encoding topoisomerase-IIβ) protects cardiomyocytes from doxorubicin-induced DNA double-strand breaks and transcriptome changes that are responsible for defective mitochondrial biogenesis and ROS formation.

TL;DR: The results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1α stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation.

TL;DR: Adult peripheral blood CD34+ cells can transdifferentiate into cardiomyocytes, mature endothelial cells, and smooth muscle cells in vivo, however, transdifferentiation is augmented significantly by local tissue injury.

TL;DR: Both cell fusion and transdifferentiation may account for the transformation of peripheral blood CD34+ cells into cardiomyocytes in vivo.

TL;DR: It is shown that cadherin-11 (also known as osteoblast-cadherin) was highly expressed in prostate cancer cell line derived from bone metastases and had strong homophilic binding to recombinant cadherIn-11 in vitro.