Suman De

TL;DR: It is found that soluble aggregates formed at different stages of the aggregation process of amyloid beta (Aβ42) induce the disruption of lipid bilayers and an inflammatory response to different extents, suggesting that different toxic mechanisms driven by different soluble aggregated species of Aβ42 may contribute to the onset and progression of Alzheimer’s disease.

TL;DR: Peroxidation of polyunsaturated fatty acids underlies the incorporation of β-sheet-rich aggregates into the membranes, and that additionally induces neuronal death, which suggests a role for ferroptosis in Parkinson’s disease, and highlights a new mechanism by which lipid peroxidation causes cell death.

TL;DR: It is found that Hsp70 blocks the early stages of t Tau aggregation by suppressing the formation of tau nuclei, and sequesters oligomers and mature tau fibrils with nanomolar affinity into a protective complex, efficiently neutralizing their ability to damage membranes and seed further tau aggregation.

TL;DR: It is shown that Mn PL emission can vary over a much wider range and exhibit widths substantially lower than reported so far, opening newer application possibilities and requiring a fundamental shift in the perception of the emission from Mn-doped semiconductor nanocrystals.

TL;DR: The effect of moisture absorption on swelling and softening of PVP thin films was investigated by visualizing the diffusion dynamics of rhodamine 6G (Rh6G) tracer molecules at various ambient relative humidities (RH).