S
Sumanta Goswami
Researcher at Albert Einstein College of Medicine
Publications - 45
Citations - 6375
Sumanta Goswami is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Metastasis & Breast cancer. The author has an hindex of 29, co-authored 42 publications receiving 5871 citations. Previous affiliations of Sumanta Goswami include All India Institute of Medical Sciences & Yeshiva University.
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Journal ArticleDOI
Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-Kinase
Huan Pang,Rory J. Flinn,Antonia Patsialou,Jeffrey B. Wyckoff,Evanthia T. Roussos,Haiyan Wu,Maria Pozzuto,Sumanta Goswami,John S. Condeelis,Anne R. Bresnick,Jeffrey E. Segall,Jonathan M. Backer +11 more
TL;DR: These observations suggest that, when compared with kinase domain mutations in a genetically identical background, expression of helical domain mutants of p110alpha produce a more severe metastatic phenotype.
Journal ArticleDOI
Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult.
Sumanta Goswami,Nancy L. Sheets,Jiři Zavadil,Bharesh K. Chauhan,Erwin P. Bottinger,Venkat N. Reddy,Marc Kantorow,Ales Cvekl +7 more
TL;DR: The present data provide a global perspective on those genes that respond to acute OS, point to novel genes and pathways associated with OS, and set the groundwork for understanding the functions of OS-related genes in lens protection and disease.
Journal ArticleDOI
Mena invasive (MenaINV) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM
Evanthia T. Roussos,Sumanta Goswami,Sumanta Goswami,Michele Balsamo,Yarong Wang,Robert Stobezki,Esther Adler,Brian D. Robinson,Joan G. Jones,Frank B. Gertler,John S. Condeelis,Maja H. Oktay +11 more
TL;DR: It is demonstrated that mouse mammary tumors generated from EGFP-MenaINV expressing tumor cells are significantly less cohesive and have discontinuous cell–cell contacts compared to Mena11a xenografts, suggesting that MenaINV is the isoform associated with breast cancer cell discohesion, invasion and intravasation in mice and in humans.
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The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration.
Shu Chin Yip,Mirvat El-Sibai,Salvatore J. Coniglio,Ghassan Mouneimne,Robert J. Eddy,Beth E. Drees,Paul O. Neilsen,Sumanta Goswami,Marc Symons,John S. Condeelis,Jonathan M. Backer +10 more
TL;DR: The data show that in EGF-stimulated MTLn3 carcinoma cells, Ras is required for both PtdIns(3,4,5)P3 production and lamellipod extension, whereas Rac1 is needed for formation of adhesive structures, which suggest an unappreciated role for Ras during protrusion, and a crucial role for Rac in the stabilization of protrusions required for cell motility.
Journal ArticleDOI
Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapy.
TL;DR: The capability of using a rat alograft model for evaluating the apoptotic status of a migratory subpopulation of tumor cells and the ability to study their resistance to chemotherapeutic agents directly are indicated.