S
Suresh Mahalingam
Researcher at Griffith University
Publications - 130
Citations - 5650
Suresh Mahalingam is an academic researcher from Griffith University. The author has contributed to research in topics: Virus & Chikungunya. The author has an hindex of 37, co-authored 116 publications receiving 4683 citations. Previous affiliations of Suresh Mahalingam include Indian Institute of Technology Madras & RMIT University.
Papers
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Journal ArticleDOI
Macrophage Migration Inhibitory Factor Receptor CD74 Mediates Alphavirus-Induced Arthritis and Myositis in Murine Models of Alphavirus Infection
Lara J. Herrero,Kuo Ching Sheng,Peng Jian,Adam Taylor,Zhisheng Her,Belinda L. Herring,Angela Chow,Yee Sin Leo,Michael J. Hickey,Eric F Morand,Lisa F. P. Ng,Richard Bucala,Suresh Mahalingam +12 more
TL;DR: It is suggested that both MIF and CD74 play a critical role in mediating alphaviral disease, and blocking these factors with novel therapeutic agents could substantially ameliorate the pathologic manifestations.
Journal ArticleDOI
Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis.
TL;DR: Testing the effect of treating RRV-induced arthritis using the anti-tumor necrosis factor (anti-TNF) drug etanercept in a mouse model of rheumatic disease found it unlikely to be useful in treating alphaviral arthritides.
Pentraxins and Collectins: Friend or Foe during Pathogen
TL;DR: The protective and pathogenic effects of pentraxins and collectins are discussed, as well as their therapeutic significance, in the field of innate immunity.
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Effects of an in-frame deletion of the 6k gene locus from the genome of Ross River virus
Adam Taylor,Julian V. Melton,Lara J. Herrero,Lara J. Herrero,Bastian Thaa,Liis Karo-Astover,Peter W. Gage,Michelle Nelson,Kuo-Ching Sheng,Brett A. Lidbury,Gary Ewart,Gerald M. McInerney,Andres Merits,Suresh Mahalingam,Suresh Mahalingam +14 more
TL;DR: The results show that the 6K proteins may contribute to alphaviral disease manifestations and suggest that manipulation of the 6k gene may be a potential strategy to facilitate viral vaccine development, and could lead to the development of safer and more immunogenicAlphavirus vectors for vaccine delivery.
Journal ArticleDOI
Mutations in nsP1 and PE2 are critical determinants of Ross River virus-induced musculoskeletal inflammatory disease in a mouse model
Henri J. Jupille,Lauren M. Oko,Kristina A. Stoermer,Mark T. Heise,Suresh Mahalingam,Bronwyn M. Gunn,Thomas E. Morrison +6 more
TL;DR: It is shown that determinants in both nsP1 and PE2 have critical and distinct roles in the pathogenesis of RRV-induced musculoskeletal inflammatory disease in mice and that full virulence to the DC5692 strain is restored.