M
Michael J. Hickey
Researcher at Monash Medical Centre
Publications - 184
Citations - 9284
Michael J. Hickey is an academic researcher from Monash Medical Centre. The author has contributed to research in topics: Inflammation & Cell adhesion molecule. The author has an hindex of 50, co-authored 171 publications receiving 8344 citations. Previous affiliations of Michael J. Hickey include Ottawa Hospital Research Institute & Monash University.
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Journal ArticleDOI
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen,Regina M. Krohn,Hongqi Lue,Julia L. Gregory,Alma Zernecke,Rory R. Koenen,Manfred Dewor,Ivan T. Georgiev,Andreas Schober,Lin Leng,Teake Kooistra,Gunter Fingerle-Rowson,Pietro Ghezzi,Robert Kleemann,Shaun R. McColl,Richard Bucala,Michael J. Hickey,Christian Weber +17 more
TL;DR: Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition and displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.
Journal ArticleDOI
Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia.
Michael J. Hickey,Keith A. Sharkey,Elaine Sihota,Paul H. Reinhardt,John D. MacMicking,Carl Nathan,Paul Kubes +6 more
TL;DR: iNOS induced in response to LPS releases NO that is capable of reducing leukocyte accumulation by affecting leukocytes directly and raises the possibility that induction of iNOS is a homeostatic regulator forLeukocyte recruitment.
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Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection
Arby Abtin,Rohit Jain,Andrew J. Mitchell,Ben Roediger,Anthony J. Brzoska,Shweta Tikoo,Qiang Cheng,Lai Guan Ng,Lois L. Cavanagh,Ulrich H. von Andrian,Michael J. Hickey,Neville Firth,Wolfgang Weninger +12 more
TL;DR: Using multiphoton intravital microscopy, it is shown that neutrophils extravasate from inflamed dermal venules in close proximity to perivascular macrophages, which are a major source of neutrophil chemoattractants.
Journal ArticleDOI
Intravascular immunity: the host–pathogen encounter in blood vessels
Michael J. Hickey,Paul Kubes +1 more
TL;DR: In vivo imaging studies that examine the behaviour of both the immune system and bacteria in the highly dynamic microvasculature are highlighted, highlighting previously unappreciated functions of this intravascular aspect of theimmune system.
Journal ArticleDOI
A Role for Platelets and Endothelial Selectins in Tumor Necrosis Factor-α–Induced Leukocyte Recruitment in the Brain Microvasculature
Juliana Carvalho-Tavares,Michael J. Hickey,Jamie Hutchison,Jean Michaud,Ian T. Sutcliffe,Paul Kubes +5 more
TL;DR: Investigation of the leukocyte recruitment in the brain microcirculation by intravital microscopy revealed that the recruitment was primarily of neutrophils, suggesting a role for endothelial P-selectin in cerebral leukocytes recruitment.