Suresh Mahalingam

TL;DR: It is shown that primary human osteoblasts (hOBs) can be productively infected by RRV, and that OBs are capable of producing proinflammatory mediators during alphavirus-induced arthralgia.

TL;DR: Although IL‐25 up‐regulates IL‐13 in the lung, the contribution of this and other type 2 cytokine signalling pathways to the induction and persistence of airways hyper‐reactivity (AHR) and allergic inflammation are unclear.

TL;DR: Recent identification of Hendra virus infection in a domestic animal outside the laboratory setting, and the large range of pteropid bats in Australia, underpins the potential of this virus to cause greater morbidity and mortality in both rural and urban populations and its importance to both veterinary and human health.

TL;DR: It is demonstrated here that the complement system, an important component of the innate immune response, enhances the severity of RRV-induced disease in mice and suggested that complement plays an essential role in the effector phase, but not the inductive phase, of RRv-induced arthritis and myositis.

TL;DR: Alphaviruses were used to determine whether viruses grown in mosquito cells differed from mammalian-cell-derived viruses in their ability to induce type I interferon (IFN) responses in infected primary dendritic cells, and results suggest that the viruses initially delivered by the mosquito vector differ from those generated in subsequent rounds of replication in the host.