Susan C. Maness

TL;DR: This article investigated the effect of BPA on the immature rat uterus and found that BPA antagonized the E2 stimulatory effects on both peroxidase activity and PR levels but did not inhibit E2-induced increases of uterine weight.

TL;DR: Some of the structural requirements for ERα and ERβ activity are identified and the complexity involved in determining the mechanism of action of endocrine-active chemicals that simultaneously act as agonists or antagonists through one or more hormone receptors is demonstrated.

TL;DR: Radioactivity in pup carcasses indicated exposure in the range of microgram equivalents per kilogram; those values ranged from 44.3 +/- 24.4 for pups separated from their lactating dams at 2 h to 78.4 +/- 10.9 at 24 h, indicating that metabolism via glucuronidation is a detoxication reaction.

TL;DR: 2,2-bis-(p-hydroxyphenyl)-1, 1,1,1-trichloroethane (HPTE), an estrogenic metabolite of the organochlorine pesticide methoxychlor, at estrogen receptor α (ERα) and estrogen receptor β (ERβ), which was a potent ERα agonist in HepG2 cells and HPTE had minimal agonist acti...

TL;DR: The results demonstrate that the HepG2 assay is a sensitive and specific method for detecting chemical interaction with the androgen receptor, and should be useful for determining the role of multiple steroid receptors in the mechanism of action of endocrine active chemicals.