Showing papers in "Molecular and Cellular Endocrinology in 1998"

TL;DR: This article investigated the effect of BPA on the immature rat uterus and found that BPA antagonized the E2 stimulatory effects on both peroxidase activity and PR levels but did not inhibit E2-induced increases of uterine weight.

TL;DR: IGBPs are important molecules for regulating the bioavailability of IGF-I and -II to receptors and understanding the variables that regulate their abundance may lead to a better understanding of the factors that regulate IGF action in skeletal tissues.

TL;DR: It is predicted that to prevent accumulation of mild mitochondrial genomes in the population there is a need for physiological female sterility prior to total depletion of ovarian oocytes, a phenomenon for which there is empirical evidence and which the authors term the oöpause.

TL;DR: Throughout oocyte development follicle cell support is fundamental to provide the germ line cell with nutrients and growth regulators to ensure progression through the protracted growth phase, and the oocyte actively promotes growth and differentiation of the follicular cells.

TL;DR: This review will focus on several genes shown to control the ovulation process, including specific ovarian cell types, diverse signaling pathways and temporally controlled expression of specific genes.

TL;DR: The placenta can no longer be considered merely a passive conduit for fetal nutrition, Rather, it is actively involved in the integration of nutritional and endocrine signals from the maternal and fetal somatotrophic axes.

TL;DR: When quantity and quality of antral follicles drop below a critical threshold, there is a subsequent drop in inhibine B resulting in the selective FSH rise at a mean age of 37-38 years, which explains the accelerated follicle depletion.

TL;DR: The cloning and analysis of ecdysteroid receptor (bpEcR) and retinoid-X receptor (UpRXR) cDNA homologs from the fiddler crab Uca pugilator show that the deduced amino acid sequence of this crustacean EcR most closely resembles the insect EcRs within the DNA binding and ligand binding domains (LBDs).

TL;DR: In this article, the diversity of both GLP-1 and glucagon activity was highlighted by studying the tissue distribution of glucagon and GLP1 receptor gene expression by both Southern blot analysis of RT-PCR products and nuclease protection assays.

TL;DR: The largest effect of 1,25(OH)2D3 on cell proliferation is likely due to a TGF-beta independent mechanism of action, while the cell cycle regulatory genes, cyclin D1 and p27, are probably involved herein as their expression was not affected by the presence of neutralising antibodies.

TL;DR: Anti-Müllerian (AMH), a member of the transforming growth factor beta produced by immature Sertoli cells and, to a lesser degree, by granulosa cells from birth to the end of reproductive life, does not affect gonadal determination but has a negative effect upon gonadal development in both sexes.

TL;DR: The roles of DNA binding-dependent and -independent transcriptional modes of action in development and physiology as exemplified by the analysis of glucocorticoid receptor function are discussed.

TL;DR: The brain-derived cDNA had 53% and 61-62% sequence identity when compared with human placental and fish ovarian P450arom forms, respectively, and higher homologies in conserved functional domains.

TL;DR: Estrogen receptor (ER)- β mRNA splice variants have been identified in human breast tumors as well as normal human and mouse ovarian, uterine and mammary tissues.

TL;DR: The results suggest that bone is an extraglandular source of local estrogen which plays an important role in bone mineral metabolism through autocrine and paracrine actions.

TL;DR: Multiple coactivators have been identified that fit the definition of a protein that connects or bridges the DNA-bound receptor to proteins in the preinitiation complex and thereby enhance transcription and indicates a dual role for coactivator as bridging factors and chromatin remodeling proteins.

TL;DR: Assays of PGH by specific monoclonal antibodies reveal that in the maternal circulation from 15-20 weeks up to term, PGH gradually replaces pituitary growth hormone which becomes undetectable, which may have important implications for physiological adjustment to gestation and especially in the control of maternal IGF1 levels.

TL;DR: It is suggested that in adult males, genistein induces the typical estrogenic effects in doses comparable to those present in soy-based diets, while in neonatal animals, considerably higher doses are required to show estrogen-like activity.

TL;DR: It is concluded that TNF-alpha (alone or in combination with other cytokines) is responsible for the activation of protein breakdown in skeletal muscle of tumour-bearing mice.

TL;DR: A subfamily of bicoid-related homeodomain factors was recently discovered through its involvement in transcription of pituitary-specific genes, and a second related gene was identified by positional cloning as the causative gene for Rieger's syndrome.

TL;DR: The cloning of a specific ERβ cDNA fragment and the expression of ERα and ERβ mRNAs in various endocrine and non-endocrine tissues of male and female rhesus macaques suggest that ERα mRNA is widely distributed in both female and male tissues, while ERβ mRNA is more widely distributedIn female than in male brain.

TL;DR: It is reported the identification in the mouse and human of a cDNA, STC-2, that shows significant similarity to the first mammalian STC (which is now rename STC -1), and northern analysis revealed that mammalian STD-2 is expressed in a wide variety of tissues.

TL;DR: Results show that eel P450(11beta) does not possess significant aldosterone synthesizing activity and is therefore unlikely to possess significant corticosteroid synthesis activity.

TL;DR: The pineal hormone, melatonin, inhibits proliferation of estrogen receptor (ER)-positive MCF-7 human breast cancer cells, modulates both ER mRNA and protein expression, and appears to be serum dependent, indicating interaction between melatonin and serum components.

TL;DR: Normally elevated plasma levels appear to be a prerequisite for normal GH and gonadotropin secretion in the rat, and the possibility that changing plasma levels for leptin also affect peripheral endocrine targets, such as pituitary, ovary, adrenal or pancreas, is likely.

TL;DR: The method described here reduces or eliminates many of the drawbacks of the conventional procedures used to isolate Sertoli cells, thus providing a useful tool in studies of growth kinetics and regulation of cell proliferation in vitro.

TL;DR: A better knowledge of the cellular and biochemical components involved in folliculogenesis and apoptosis should elucidate the mechanisms of POF.

TL;DR: Together these results indicate considerable potential of these agents to treat stroke, perinatal asphyxia and other forms of acute brain injury.

TL;DR: The role of PDE3 in the control of cAMP levels of oocytes has been investigated in the mammalian and amphibian ovary using pharmacological and molecular tools as discussed by the authors.

TL;DR: The hyperandrogenism of polycystic ovary syndrome (PCOS) appears to be due to dysregulation of steroidogenesis within the ovaries and adrenal glands, and there is some evidence for the existence of P450c17-independent pathways of androgen biosynthesis.