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Brandee L. Wagner
Researcher at Duke University
Publications - 19
Citations - 2413
Brandee L. Wagner is an academic researcher from Duke University. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 13, co-authored 18 publications receiving 2344 citations. Previous affiliations of Brandee L. Wagner include Exelixis & Salk Institute for Biological Studies.
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Journal ArticleDOI
Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol
Janet C. Gould,Linda S. Leonard,Susan C. Maness,Brandee L. Wagner,Kevin Conner,Timothy R. Zacharewski,Steve Safe,Donald P. McDonnell,Kevin W. Gaido +8 more
TL;DR: This article investigated the effect of BPA on the immature rat uterus and found that BPA antagonized the E2 stimulatory effects on both peroxidase activity and PR levels but did not inhibit E2-induced increases of uterine weight.
Journal ArticleDOI
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
Rajendra K. Tangirala,Eric D. Bischoff,Sean B. Joseph,Brandee L. Wagner,Robert Walczak,Bryan A. Laffitte,Chris L. Daige,Diane Thomas,Richard A. Heyman,David J. Mangelsdorf,Xuping Wang,Aldons J. Lusis,Peter Tontonoz,Ira G. Schulman +13 more
TL;DR: Elimination of LXR activity in bone marrow-derived cells mimics many aspects of Tangier disease, a human high density lipoprotein deficiency, including aberrant regulation of cholesterol transporter expression, lipid accumulation in macrophages, splenomegaly, and increased atherosclerosis.
Journal ArticleDOI
Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor
Thierry Claudel,Mark D. Leibowitz,Catherine Fievet,Anne Tailleux,Brandee L. Wagner,Joyce J. Repa,Gérard Torpier,Jean-Marc A. Lobaccaro,James R. Paterniti,David J. Mangelsdorf,Richard A. Heyman,Johan Auwerx,Johan Auwerx +12 more
TL;DR: Activation of ABC-1-mediated cholesterol efflux by the RXR/LXR heterodimer might contribute to the beneficial effects of rexinoids on atherosclerosis and warrant further evaluation of RXR or LXR agonists in prevention and treatment of Atherosclerosis.
Journal ArticleDOI
The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor
TL;DR: It is proposed that 8-bromo-cAMP-mediated potentiation of PR transcriptional activity is due, at least in part, to a disruption of the interaction between PR and the corepressors NCoR and SMRT.
Journal ArticleDOI
Promoter-Specific Roles for Liver X Receptor/Corepressor Complexes in the Regulation of ABCA1 and SREBP1 Gene Expression
Brandee L. Wagner,Annabel F. Valledor,Gang Shao,Chris L. Daige,Eric D. Bischoff,Mary Petrowski,Kristen Jepsen,Sung Hee Baek,Richard A. Heyman,Michael G. Rosenfeld,Ira G. Schulman,Christopher K. Glass +11 more
TL;DR: It is reported that high-density-lipoprotein (HDL) cholesterol levels are increased in LXR-deficient mice, suggesting that derepression of ABCA1 and possibly other LXR target genes in selected tissues is sufficient to result in enhanced HDL biogenesis at the whole-body level.