R
Rustom Antia
Researcher at Emory University
Publications - 153
Citations - 12621
Rustom Antia is an academic researcher from Emory University. The author has contributed to research in topics: Population & Immune system. The author has an hindex of 48, co-authored 140 publications receiving 10955 citations. Previous affiliations of Rustom Antia include Imperial College London & University of Massachusetts Amherst.
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Journal ArticleDOI
Lineage relationship and protective immunity of memory CD8 T cell subsets.
E. John Wherry,Volker Teichgräber,Todd C. Becker,David Masopust,Susan M. Kaech,Rustom Antia,Ulrich H. von Andrian,Rafi Ahmed +7 more
TL;DR: It is proposed that TCM and TEM do not necessarily represent distinct subsets, but are part of a continuum in a linear naive → effector → TEM → TCM differentiation pathway.
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Humoral immunity due to long-lived plasma cells
TL;DR: A substantial fraction of plasma cells can survive and continue to secrete antibody for extended periods of time in the absence of any detectable memory B cells, demonstrating a new mechanism by which humoral immunity is maintained.
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Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells
Todd C. Becker,E. John Wherry,David L. Boone,Kaja Murali-Krishna,Rustom Antia,Averil Ma,Rafi Ahmed +6 more
TL;DR: Results show that IL-15 is not essential for the generation of memory CD8 T cells, but is required for homeostatic proliferation to maintain populations of memory cells over long periods of time.
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Emerging pathogens: the epidemiology and evolution of species jumps
TL;DR: It is concluded that, although pathogen emergence is inherently unpredictable, emerging pathogens tend to share some common traits, and that directly transmitted RNA viruses might be the pathogens that are most likely to jump between host species.
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Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells
Joseph N. Blattman,Rustom Antia,David J. D. Sourdive,Xiaochi Wang,Susan M. Kaech,Kaja Murali-Krishna,John D. Altman,Rafi Ahmed +7 more
TL;DR: The constraint of fitting a diverse repertoire of antigen specificities in a limited total population of lymphocytes results in the frequency of naive cells specific for any given antigen being below the limit of detection by direct measurement, and this precursor frequency is estimated by titrating a known quantity of antigen-specific cells into naive recipients.